Nature Communications (Sep 2019)
Discovering genetic interactions bridging pathways in genome-wide association studies
- Gang Fang,
- Wen Wang,
- Vanja Paunic,
- Hamed Heydari,
- Michael Costanzo,
- Xiaoye Liu,
- Xiaotong Liu,
- Benjamin VanderSluis,
- Benjamin Oately,
- Michael Steinbach,
- Brian Van Ness,
- Eric E. Schadt,
- Nathan D. Pankratz,
- Charles Boone,
- Vipin Kumar,
- Chad L. Myers
Affiliations
- Gang Fang
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Wen Wang
- Department of Computer Science and Engineering, University of Minnesota
- Vanja Paunic
- Department of Computer Science and Engineering, University of Minnesota
- Hamed Heydari
- Donnelly Centre, University of Toronto
- Michael Costanzo
- Donnelly Centre, University of Toronto
- Xiaoye Liu
- Department of Computer Science and Engineering, University of Minnesota
- Xiaotong Liu
- Department of Computer Science and Engineering, University of Minnesota
- Benjamin VanderSluis
- Department of Computer Science and Engineering, University of Minnesota
- Benjamin Oately
- Department of Computer Science and Engineering, University of Minnesota
- Michael Steinbach
- Department of Computer Science and Engineering, University of Minnesota
- Brian Van Ness
- Department of Genetics, Cell Biology, and Development, University of Minnesota
- Eric E. Schadt
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Nathan D. Pankratz
- Department of Laboratory Medicine and Pathology, University of Minnesota
- Charles Boone
- Donnelly Centre, University of Toronto
- Vipin Kumar
- Department of Computer Science and Engineering, University of Minnesota
- Chad L. Myers
- Department of Computer Science and Engineering, University of Minnesota
- DOI
- https://doi.org/10.1038/s41467-019-12131-7
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 18
Abstract
Genetic interactions may contribute to phenotypic traits but are challenging to decipher. Here, the authors develop BridGE, a computational approach for identifying pathways connected by genetic interactions from GWAS data.
