Терапевтический архив (Aug 2011)

Current methods of diagnosis and monitoring of a systemic amyloidosis course

  • Vilen Vilevich Rameev,
  • Lidiya Vladimirovna Kozlovskaya,
  • Elena Aleksandrovna Malinina,
  • Anna Grigor'evna Serova,
  • Ivetta Nikolaevna Kogarko,
  • Bronislav Stanislavovich Kogarko,
  • Nina Vasil'evna Lyubimova,
  • V V Rameev,
  • L V Kozlovskaya,
  • E A Malinina,
  • A G Serova,
  • I N Kogarko,
  • B S Kogarko,
  • N V Lyubimova

Journal volume & issue
Vol. 83, no. 8
pp. 48 – 54

Abstract

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Aim. To determine clinical significance of measuring blood levels of protein precursors of AA- and AL-amyloidosis - SAA and immunoglobulin free light chains (ILC), respectively. Material and methods. SAA concentrations were studied with ELISA in 43 rheumatoid arthritis (RA) patients including complicated with reactive AA-amyloidosis (n = 31). Inflammation activity and its severity were studied (indices Li, richi, HAQ, DAS4). A modern quantitative nephelometric method Freelite estimated ILC levels in 31 patients with AL-amyloidosis. Results. Patients with RA complicated with AA-amyloidosis and free of it had a strong correlation between blood serum SAA concentration and activity of joint disease. Elevated SAA concentrations to 160 mg/l (normal 10 mg/l) were detected in many patients with clinical remission of the joint syndrome. Significal inhibition of AA-amyloidosis progression was seen only in SAA concentration drop under 60 mg/l. For AL-amyloidosis patients ILC fall by less than 3 normal value means a 6-time increase in chances of a favourable outcome. Conclusion. Monitoring of blood levels of proteins precursors of AA- and AL-amyloidosis is a key factor in prognosis of the disease and treatment efficacy.

Keywords