Nature Communications (Oct 2018)
HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons
- Sarah Kishinevsky,
- Tai Wang,
- Anna Rodina,
- Sun Young Chung,
- Chao Xu,
- John Philip,
- Tony Taldone,
- Suhasini Joshi,
- Mary L. Alpaugh,
- Alexander Bolaender,
- Simon Gutbier,
- Davinder Sandhu,
- Faranak Fattahi,
- Bastian Zimmer,
- Smit K. Shah,
- Elizabeth Chang,
- Carmen Inda,
- John Koren,
- Nathalie G. Saurat,
- Marcel Leist,
- Steven S. Gross,
- Venkatraman E. Seshan,
- Christine Klein,
- Mark J. Tomishima,
- Hediye Erdjument-Bromage,
- Thomas A. Neubert,
- Ronald C. Henrickson,
- Gabriela Chiosis,
- Lorenz Studer
Affiliations
- Sarah Kishinevsky
- The Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center
- Tai Wang
- Program in Chemical Biology, Memorial Sloan Kettering Cancer Center
- Anna Rodina
- Program in Chemical Biology, Memorial Sloan Kettering Cancer Center
- Sun Young Chung
- The Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center
- Chao Xu
- Program in Chemical Biology, Memorial Sloan Kettering Cancer Center
- John Philip
- Proteomics Core Facility, Memorial Sloan Kettering Cancer Center
- Tony Taldone
- Program in Chemical Biology, Memorial Sloan Kettering Cancer Center
- Suhasini Joshi
- Program in Chemical Biology, Memorial Sloan Kettering Cancer Center
- Mary L. Alpaugh
- Program in Chemical Biology, Memorial Sloan Kettering Cancer Center
- Alexander Bolaender
- Program in Chemical Biology, Memorial Sloan Kettering Cancer Center
- Simon Gutbier
- Doerenkamp-Zbinden Chair for In Vitro Toxicology and Biomedicine, University of Konstanz
- Davinder Sandhu
- Department of Pharmacology, Weill Cornell College of Medicine
- Faranak Fattahi
- The Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center
- Bastian Zimmer
- The Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center
- Smit K. Shah
- Program in Chemical Biology, Memorial Sloan Kettering Cancer Center
- Elizabeth Chang
- Proteomics Core Facility, Memorial Sloan Kettering Cancer Center
- Carmen Inda
- Program in Chemical Biology, Memorial Sloan Kettering Cancer Center
- John Koren
- Program in Chemical Biology, Memorial Sloan Kettering Cancer Center
- Nathalie G. Saurat
- The Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center
- Marcel Leist
- Doerenkamp-Zbinden Chair for In Vitro Toxicology and Biomedicine, University of Konstanz
- Steven S. Gross
- Department of Pharmacology, Weill Cornell College of Medicine
- Venkatraman E. Seshan
- Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center
- Christine Klein
- Institute of Neurogenetics, University of Lübeck
- Mark J. Tomishima
- The Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center
- Hediye Erdjument-Bromage
- Department of Cell Biology, NYU School of Medicine
- Thomas A. Neubert
- Department of Cell Biology, NYU School of Medicine
- Ronald C. Henrickson
- Proteomics Core Facility, Memorial Sloan Kettering Cancer Center
- Gabriela Chiosis
- Program in Chemical Biology, Memorial Sloan Kettering Cancer Center
- Lorenz Studer
- The Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center
- DOI
- https://doi.org/10.1038/s41467-018-06486-6
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
The early molecular events that ultimately lead to neuronal cell death in pathologies such as Parkinson’s disease are poorly understood. Here the authors use pluripotent stem-cell-derived human midbrain neurons and chemical biology tools to gain molecular level insight into the events induced by toxic and genetic stresses that mimic those occurring during neurodegeneration.
