Correction of metabolic disorders in secondary acetonemic syndrome on the background of acute respiratory infection in children

Abstract

Acetonemic syndrome (AS) is one of the most frequent metabolic disorders in children. Despite the large number of works on the pathogenesis of hyperketonemia, the role of the processes of cellular energy metabolism in the development of this condition has not been finally clarified. The study of the metabolism energy balance makes it possible to identify important pathogenetic links, prognostic criteria for the occurrence and course of AS, and also to determine approaches to its correction. A comparative controlled study was conducted among 64 children with secondary AS on the background of inflammatory diseases of the respiratory tract: acute rhinopharyngitis, acute simple bronchitis, acute laryngotracheitis, community-acquired pneumonia, acute tracheitis, acute obstructive bronchitis. The work identified significant predictors for the occurrence of the AS. Statistically significant relationship was revealed between the level of acetonuria and the severity of the patient’s condition. In order to correct the AS, the combination balanced preparation Ionica was used in 36 children of the main group. The use of the glucose-containing drug Ionica allowed improving the activity of energy metabolism enzymes (succinate dehydrogenase, lactate dehydrogenase, glycerophosphate dehydrogenase, glutamate dehydrogenase), reduce the duration of AS manifestations in the main group, as well as the need for infusion therapy.

Keywords

• acetonemic syndrome
• children
• energy shortage
• metabolic correction