Research progress on the mechanism of food-derived antihypertensive peptides

WANG Baobei; ZHANG Hui; LIU Yusong; CHEN Hongbin; GUO Fengxian; ZHENG Zongping

doi:10.13652/j.spjx.1003.5788.2023.80842

Shipin yu jixie (Apr 2024)

Research progress on the mechanism of food-derived antihypertensive peptides

WANG Baobei,
ZHANG Hui,
LIU Yusong,
CHEN Hongbin,
GUO Fengxian,
ZHENG Zongping

Affiliations

WANG Baobei: Fujian Province Key Laboratory for the Development of Bioactive Material from Marine Algae, College of Oceanology and Food Science, Quanzhou Normal University, Quanzhou, Fujian 362000 , China
ZHANG Hui: Fujian Province Key Laboratory for the Development of Bioactive Material from Marine Algae, College of Oceanology and Food Science, Quanzhou Normal University, Quanzhou, Fujian 362000 , China
LIU Yusong: Fujian Province Key Laboratory for the Development of Bioactive Material from Marine Algae, College of Oceanology and Food Science, Quanzhou Normal University, Quanzhou, Fujian 362000 , China
CHEN Hongbin: Fujian Province Key Laboratory for the Development of Bioactive Material from Marine Algae, College of Oceanology and Food Science, Quanzhou Normal University, Quanzhou, Fujian 362000 , China
GUO Fengxian: Fujian Province Key Laboratory for the Development of Bioactive Material from Marine Algae, College of Oceanology and Food Science, Quanzhou Normal University, Quanzhou, Fujian 362000 , China
ZHENG Zongping: Fujian Province Key Laboratory for the Development of Bioactive Material from Marine Algae, College of Oceanology and Food Science, Quanzhou Normal University, Quanzhou, Fujian 362000 , China

DOI: https://doi.org/10.13652/j.spjx.1003.5788.2023.80842
Journal volume & issue: Vol. 40, no. 3
pp. 217 – 224

Abstract

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In this review, several mechanisms of antihypertensive peptides derived from food and its by-products were summarized. Mechanisms based on the RAAS system such as ACE/Ang Ⅱ/AT1R signaling pathways and ACE2/Ang (1-7)/MasR signaling pathways were included. Mechanisms targeting at KNOS system including PI3K/Akt/eNOS signaling pathway, PPAR-γ/caspase3/MAPK/eNOS signaling pathway and L-type Ca2+ channel were also discussed. In addition, the pathways of reducing blood pressure by inhibiting endothelin-converting enzyme (ECE) activity discovered in recent years were also introduced.

Published in Shipin yu jixie

ISSN: 1003-5788 (Print)
Publisher: The Editorial Office of Food and Machinery
Country of publisher: China
LCC subjects: Technology: Chemical technology: Food processing and manufacture
Website: http://www.ifoodmm.com/spyjxen/home

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