EPJ Nuclear Sciences & Technologies (Jan 2023)
Health effects of ionising radiation in paediatrics undergoing either cardiac fluoroscopy or modern radiotherapy (The HARMONIC project)
- Thierry-Chef Isabelle,
- Timmermann Beate,
- Journy Neige,
- Bernier Marie-Odile,
- McNally Richard,
- Dabin Jérémie,
- Brualla Lorenzo,
- Haghdoost Siamak,
- Sarukhan Adelaida,
- Haustermans Karin,
- De Wit Inge,
- Isebaert Sofie,
- Lassen-Ramshad Yasmin,
- Tram Henriksen Louise,
- Høyer Morten,
- Toussaint Laura,
- Boissonnat Guillaume,
- Thariat Juliette,
- Demoor-Goldschmidt Charlotte,
- Haddy Nadia,
- Bolle Stéphanie,
- Fresneau Brice,
- Belhout Amel,
- Dreger Steffen,
- Zeeb Hajo,
- Grazia Andreassi Maria,
- Campolo Jonica,
- Picano Eugenio,
- Jahnen Andreas,
- Ronckers Cécile,
- Maduro John H.,
- Kjaerheim Kristina,
- Døhlen Gaute,
- Robsahm Trude Eid,
- Olerud Hilde M.,
- Thevathas Utheya Salini,
- Afroz Susmita,
- Helge Østerås Bjørn,
- Schneider Uwe,
- Walsh Linda,
- Dumas Agnès,
- Jackson Angéla,
- Rage Estelle,
- De Saint-Hubert Marijke,
- Hardy Richard,
- Bäumer Christian,
- Steinmeier Theresa,
- Botzenhardt Suzan,
- Wette Martina,
- Ortiz Rodney,
- Chumak Vadim
Affiliations
- Thierry-Chef Isabelle
- Barcelona Institute for Global Health (ISGlobal)
- Timmermann Beate
- University Hospital Essen (UK Essen)
- Journy Neige
- French National Institute of Health and Medical Research (Inserm), Gustave Roussy
- Bernier Marie-Odile
- Institut de Radioprotection et de Sûreté Nucléaire (IRSN)
- McNally Richard
- Population Health Science Institute, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary
- Dabin Jérémie
- Belgian Nuclear Research Centre (SCK CEN)
- Brualla Lorenzo
- West German Proton Therapy Centre Essen (WPE)
- Haghdoost Siamak
- Stockholm University (SU), Universitetsvagen 10
- Sarukhan Adelaida
- Barcelona Institute for Global Health (ISGlobal)
- Haustermans Karin
- Katholieke Universiteit Leuven (KU Leuven)
- De Wit Inge
- Katholieke Universiteit Leuven (KU Leuven)
- Isebaert Sofie
- Katholieke Universiteit Leuven (KU Leuven)
- Lassen-Ramshad Yasmin
- Department of Pediatric and Adolescent Medicine, Aarhus University Hospital (AUH)
- Tram Henriksen Louise
- Department of Pediatric and Adolescent Medicine, Aarhus University Hospital (AUH)
- Høyer Morten
- Aarhus University (AU)
- Toussaint Laura
- Aarhus University (AU)
- Boissonnat Guillaume
- Commissariat à l’Énergie Atomique & aux Énergies Alternatives (CEA)
- Thariat Juliette
- Centre Régional François Baclesse (CRFB)
- Demoor-Goldschmidt Charlotte
- French National Institute of Health and Medical Research (Inserm), Gustave Roussy
- Haddy Nadia
- Gustave Roussy (GR)
- Bolle Stéphanie
- Gustave Roussy (GR)
- Fresneau Brice
- Gustave Roussy (GR)
- Belhout Amel
- Gustave Roussy (GR)
- Dreger Steffen
- Leibniz-Institute for Prevention Research & Epidemiology (BIPS)
- Zeeb Hajo
- Leibniz-Institute for Prevention Research & Epidemiology (BIPS)
- Grazia Andreassi Maria
- Institute of Clinical Physiology – National Research Council (IFC-CNR)
- Campolo Jonica
- Institute of Clinical Physiology – National Research Council (IFC-CNR)
- Picano Eugenio
- Institute of Clinical Physiology – National Research Council (IFC-CNR)
- Jahnen Andreas
- Luxembourg Institute of Science and Technology (LIST)
- Ronckers Cécile
- Princess Maxima Center for Paediatric Oncology (PMC)
- Maduro John H.
- University of Groningen, University Medical Center Groningen (UMCG)
- Kjaerheim Kristina
- Cancer Registry of Norway, Department of Research
- Døhlen Gaute
- Department of Pediatric Cardiology, Oslo University (OUS)
- Robsahm Trude Eid
- Cancer Registry of Norway, Department of Research
- Olerud Hilde M.
- University of South-Eastern Norway (USN)
- Thevathas Utheya Salini
- University of South-Eastern Norway (USN)
- Afroz Susmita
- University of South-Eastern Norway (USN)
- Helge Østerås Bjørn
- Department of Physics and Computational Radiology, Oslo University (OUS)
- Schneider Uwe
- University of Zurich (UZH)
- Walsh Linda
- University of Zurich (UZH)
- Dumas Agnès
- French National Institute of Health and Medical Research (Inserm), Gustave Roussy
- Jackson Angéla
- French National Institute of Health and Medical Research (Inserm), Gustave Roussy
- Rage Estelle
- Institut de Radioprotection et de Sûreté Nucléaire (IRSN)
- De Saint-Hubert Marijke
- Belgian Nuclear Research Centre (SCK CEN)
- Hardy Richard
- Population Health Science Institute, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary
- Bäumer Christian
- West German Proton Therapy Centre Essen (WPE)
- Steinmeier Theresa
- Department of Particle Therapy – University Hospital Essen, West German Cancer Centre (WTZ)
- Botzenhardt Suzan
- Department of Particle Therapy – University Hospital Essen, West German Cancer Centre (WTZ)
- Wette Martina
- Department of Particle Therapy – University Hospital Essen, West German Cancer Centre (WTZ)
- Ortiz Rodney
- Barcelona Institute for Global Health (ISGlobal)
- Chumak Vadim
- National Research Center for Radiation Medicine (NRCRM)
- DOI
- https://doi.org/10.1051/epjn/2023009
- Journal volume & issue
-
Vol. 9
p. 22
Abstract
The use of ionising radiation (IR) for medical diagnosis and treatment procedures has had a major impact on the survival of paediatric patients. Although the benefits of these techniques lead to efficient health care, evaluation of potential associated long-term health effects is required. HARMONIC aims to better understand the increased risk of cancer and non-cancer effects after exposure to medical IR in children with cancer treated with modern external beam radiotherapy (EBRT) – radiation energy in MeV range – and in children with cardiac defects diagnosed and treated with cardiac fluoroscopy procedures (CFP) – radiation energy in keV range. The project investigates, among survivors of paediatric cancer, potential endocrine dysfunction, cardiovascular and neurovascular damage, health-related quality of life and second (and subsequent) primary cancer (SPC). The cardiac component builds a pooled cohort of approximately 90 000 paediatric patients who underwent CFP during childhood and adolescence to investigate cancer risk following exposure to IR and explore the potential effects of conditions predisposing to cancer. HARMONIC develops software tools to allow dose reconstruction in both EBRT and CFP to enable epidemiological investigations and future optimisation of treatments. With the creation of a biobank of blood and saliva samples, HARMONIC aims to provide a mechanistic understanding of radiation-induced adverse health effects and identify potential biomarkers that can predict these effects.
