Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling

Shu-Chen Liu; Tien Hsu; Yu-Sun Chang; An-Ko Chung; Shih Sheng Jiang; Chun-Nan OuYang; Chiou-Hwa Yuh; Chuen Hsueh; Ya-Ping Liu; Ngan-Ming Tsang

doi:10.1038/s41467-018-07660-6

Nature Communications (Nov 2018)

Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling

Shu-Chen Liu,
Tien Hsu,
Yu-Sun Chang,
An-Ko Chung,
Shih Sheng Jiang,
Chun-Nan OuYang,
Chiou-Hwa Yuh,
Chuen Hsueh,
Ya-Ping Liu,
Ngan-Ming Tsang

Affiliations

Shu-Chen Liu: Department of Biomedical Sciences and Engineering, National Central University
Tien Hsu: Department of Biomedical Sciences and Engineering, National Central University
Yu-Sun Chang: Molecular Medicine Research Center, Chang Gung University
An-Ko Chung: Graduate Institute of Biomedical Sciences, Chang Gung University
Shih Sheng Jiang: National Institute of Cancer Research, National Health Research Institutes
Chun-Nan OuYang: Molecular Medicine Research Center, Chang Gung University
Chiou-Hwa Yuh: Institute of Molecular and Genomic Medicine, National Health Research Institutes
Chuen Hsueh: Department of Pathology, Chang Gung Memorial Hospital at Lin-Kou
Ya-Ping Liu: Pathology Core of the Molecular Medicine Research Center, Chang Gung University
Ngan-Ming Tsang: Department of Radiation Oncology, Chang Gung Memorial Hospital and University at Lin-Kou

DOI: https://doi.org/10.1038/s41467-018-07660-6
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 16

Abstract

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Molecular pathways regulating nasopharyngeal carcinoma (NPC) metastasis are unclear. Here they report higher levels of cytoplasmic leukemia inhibitory factor (cLIF) and LIF receptor (LIFR) to correlate with higher metastasis in NPC patients, and show cLIF to promote NPC metastasis and vascular dissemination via the YAP1-FAK/PXN axis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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