iScience (Feb 2023)
Delta-Omicron recombinant escapes therapeutic antibody neutralization
- Ralf Duerr,
- Hao Zhou,
- Takuya Tada,
- Dacia Dimartino,
- Christian Marier,
- Paul Zappile,
- Guiqing Wang,
- Jonathan Plitnick,
- Sara B. Griesemer,
- Roxanne Girardin,
- Jessica Machowski,
- Sean Bialosuknia,
- Erica Lasek-Nesselquist,
- Samuel L. Hong,
- Guy Baele,
- Meike Dittmann,
- Mila B. Ortigoza,
- Prithiv J. Prasad,
- Kathleen McDonough,
- Nathaniel R. Landau,
- Kirsten St George,
- Adriana Heguy
Affiliations
- Ralf Duerr
- Department of Microbiology, NYU Grossman School of Medicine, New York, NY 10016, USA; Department of Medicine, NYU Grossman School of Medicine, New York, NY 10016, USA; Vaccine Center, NYU Grossman School of Medicine, New York, NY 10016, USA; Corresponding author
- Hao Zhou
- Department of Microbiology, NYU Grossman School of Medicine, New York, NY 10016, USA
- Takuya Tada
- Department of Microbiology, NYU Grossman School of Medicine, New York, NY 10016, USA
- Dacia Dimartino
- Genome Technology Center, Office of Science and Research, NYU Langone Health, New York, NY 10016, USA
- Christian Marier
- Genome Technology Center, Office of Science and Research, NYU Langone Health, New York, NY 10016, USA
- Paul Zappile
- Genome Technology Center, Office of Science and Research, NYU Langone Health, New York, NY 10016, USA
- Guiqing Wang
- Department of Pathology, NYU Grossman School of Medicine, New York, NY 10016, USA
- Jonathan Plitnick
- Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA
- Sara B. Griesemer
- Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA
- Roxanne Girardin
- Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA
- Jessica Machowski
- Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA
- Sean Bialosuknia
- Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA
- Erica Lasek-Nesselquist
- Bioinformatics Core, Wadsworth Center, New York State Department of Health, Albany, NY 12201, USA; Biomedical Sciences Department, School of Public Health, University at Albany, SUNY, Albany, NY 12144, USA
- Samuel L. Hong
- Department of Microbiology, Immunology and Transplantation, Laboratory for Clinical and Epidemiological Virology, Rega Institute, KU Leuven, 3000 Leuven, Belgium
- Guy Baele
- Department of Microbiology, Immunology and Transplantation, Laboratory for Clinical and Epidemiological Virology, Rega Institute, KU Leuven, 3000 Leuven, Belgium
- Meike Dittmann
- Department of Microbiology, NYU Grossman School of Medicine, New York, NY 10016, USA
- Mila B. Ortigoza
- Department of Microbiology, NYU Grossman School of Medicine, New York, NY 10016, USA; Department of Medicine, NYU Grossman School of Medicine, New York, NY 10016, USA
- Prithiv J. Prasad
- Department of Medicine, NYU Grossman School of Medicine, New York, NY 10016, USA
- Kathleen McDonough
- Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA; Biomedical Sciences Department, School of Public Health, University at Albany, SUNY, Albany, NY 12144, USA
- Nathaniel R. Landau
- Department of Microbiology, NYU Grossman School of Medicine, New York, NY 10016, USA
- Kirsten St George
- Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA; Biomedical Sciences Department, School of Public Health, University at Albany, SUNY, Albany, NY 12144, USA
- Adriana Heguy
- Genome Technology Center, Office of Science and Research, NYU Langone Health, New York, NY 10016, USA; Department of Pathology, NYU Grossman School of Medicine, New York, NY 10016, USA; Corresponding author
- Journal volume & issue
-
Vol. 26,
no. 2
p. 106075
Abstract
Summary: The emergence of recombinant viruses is a threat to public health, as recombination may integrate variant-specific features that together result in escape from treatment or immunity. The selective advantages of recombinant SARS-CoV-2 isolates over their parental lineages remain unknown. We identified a Delta-Omicron (AY.45-BA.1) recombinant in an immunosuppressed transplant recipient treated with monoclonal antibody Sotrovimab. The single recombination breakpoint is located in the spike N-terminal domain adjacent to the Sotrovimab binding site. While Delta and BA.1 are sensitive to Sotrovimab neutralization, the Delta-Omicron recombinant is highly resistant. To our knowledge, this is the first described instance of recombination between circulating SARS-CoV-2 variants as a functional mechanism of resistance to treatment and immune escape.
