Redox-enabled direct stereoconvergent heteroarylation of simple alcohols

Abstract

Synthesizing complex structures of high enantiomeric excess from racemic feedstock is an enduring challenge. Here, the authors couple racemic secondary alcohols with pyrroles to form enantioenriched 2-substituted heteroarenes, via a borrowing hydrogen mechanism using the combination of an iridium catalyst and chiral phosphoric acid.