Frontiers in Immunology (Jan 2019)
Intriguing Relationships Between Cancer and Systemic Sclerosis: Role of the Immune System and Other Contributors
- Alexandre Thibault Jacques Maria,
- Alexandre Thibault Jacques Maria,
- Alexandre Thibault Jacques Maria,
- Léo Partouche,
- Léo Partouche,
- Radjiv Goulabchand,
- Radjiv Goulabchand,
- Sophie Rivière,
- Pauline Rozier,
- Pauline Rozier,
- Pauline Rozier,
- Céline Bourgier,
- Céline Bourgier,
- Alain Le Quellec,
- Alain Le Quellec,
- Jacques Morel,
- Jacques Morel,
- Danièle Noël,
- Philippe Guilpain,
- Philippe Guilpain,
- Philippe Guilpain
Affiliations
- Alexandre Thibault Jacques Maria
- Medical School, Montpellier University, Montpellier, France
- Alexandre Thibault Jacques Maria
- Department of Internal Medicine-Multiorganic Diseases, Local Referral Center for Auto-immune Diseases, Saint-Eloi Hospital, Montpellier University, Montpellier, France
- Alexandre Thibault Jacques Maria
- IRMB, INSERM, CHU Montpellier, Montpellier University, Montpellier, France
- Léo Partouche
- Medical School, Montpellier University, Montpellier, France
- Léo Partouche
- Department of Internal Medicine-Multiorganic Diseases, Local Referral Center for Auto-immune Diseases, Saint-Eloi Hospital, Montpellier University, Montpellier, France
- Radjiv Goulabchand
- Medical School, Montpellier University, Montpellier, France
- Radjiv Goulabchand
- Department of Internal Medicine-Multiorganic Diseases, Local Referral Center for Auto-immune Diseases, Saint-Eloi Hospital, Montpellier University, Montpellier, France
- Sophie Rivière
- Department of Internal Medicine-Multiorganic Diseases, Local Referral Center for Auto-immune Diseases, Saint-Eloi Hospital, Montpellier University, Montpellier, France
- Pauline Rozier
- Medical School, Montpellier University, Montpellier, France
- Pauline Rozier
- Department of Internal Medicine-Multiorganic Diseases, Local Referral Center for Auto-immune Diseases, Saint-Eloi Hospital, Montpellier University, Montpellier, France
- Pauline Rozier
- IRMB, INSERM, CHU Montpellier, Montpellier University, Montpellier, France
- Céline Bourgier
- Medical School, Montpellier University, Montpellier, France
- Céline Bourgier
- Department of Radiation Oncology, INSERM U1194/IRCM, ICM-Val d'Aurelle, Montpellier, France
- Alain Le Quellec
- Medical School, Montpellier University, Montpellier, France
- Alain Le Quellec
- Department of Internal Medicine-Multiorganic Diseases, Local Referral Center for Auto-immune Diseases, Saint-Eloi Hospital, Montpellier University, Montpellier, France
- Jacques Morel
- Medical School, Montpellier University, Montpellier, France
- Jacques Morel
- Department of Rheumatology, Lapeyronie Hospital, Montpellier, France
- Danièle Noël
- IRMB, INSERM, CHU Montpellier, Montpellier University, Montpellier, France
- Philippe Guilpain
- Medical School, Montpellier University, Montpellier, France
- Philippe Guilpain
- Department of Internal Medicine-Multiorganic Diseases, Local Referral Center for Auto-immune Diseases, Saint-Eloi Hospital, Montpellier University, Montpellier, France
- Philippe Guilpain
- IRMB, INSERM, CHU Montpellier, Montpellier University, Montpellier, France
- DOI
- https://doi.org/10.3389/fimmu.2018.03112
- Journal volume & issue
-
Vol. 9
Abstract
Systemic sclerosis (SSc) is an autoimmune connective tissue disorder, characterized by multisystem involvement, vasculopathy, and fibrosis. An increased risk of malignancy is observed in SSc (including breast and lung cancers), and in a subgroup of patients with specific autoantibodies (i.e., anti-RNA polymerase III and related autoantibodies), SSc could be a paraneoplastic syndrome and might be directly related to an immune response against cancer. Herein, we reviewed the literature, focusing on the most recent articles, and shed light onto the potential relationship between cancer and scleroderma regarding temporal and immunological dimensions.
Keywords
- Systemic sclerosis (scleroderma)
- cancer
- immunosurveillance
- paraneopastic syndrome
- immunoediting of cancer
- autoimmunity
