Immunomodulating Hydrogels as Stealth Platform for Drug Delivery Applications

Zahra Rezaei; Dilara Yilmaz-Aykut; Fatima Mumtaza Tourk; Nicole Bassous; Margot Barroso-Zuppa; Asif Iqbal Shawl; Syed Salman Ashraf; Huseyin Avci; Shabir Hassan

doi:10.3390/pharmaceutics14102244

Pharmaceutics (Oct 2022)

Immunomodulating Hydrogels as Stealth Platform for Drug Delivery Applications

Zahra Rezaei,
Dilara Yilmaz-Aykut,
Fatima Mumtaza Tourk,
Nicole Bassous,
Margot Barroso-Zuppa,
Asif Iqbal Shawl,
Syed Salman Ashraf,
Huseyin Avci,
Shabir Hassan

Affiliations

Zahra Rezaei: Division of Engineering in Medicine, Brigham and Women’s Hospital, Department of Medicine, Harvard Medical School, Cambridge, MA 02139, USA
Dilara Yilmaz-Aykut: Division of Engineering in Medicine, Brigham and Women’s Hospital, Department of Medicine, Harvard Medical School, Cambridge, MA 02139, USA
Fatima Mumtaza Tourk: Division of Engineering in Medicine, Brigham and Women’s Hospital, Department of Medicine, Harvard Medical School, Cambridge, MA 02139, USA
Nicole Bassous: Division of Engineering in Medicine, Brigham and Women’s Hospital, Department of Medicine, Harvard Medical School, Cambridge, MA 02139, USA
Margot Barroso-Zuppa: Division of Engineering in Medicine, Brigham and Women’s Hospital, Department of Medicine, Harvard Medical School, Cambridge, MA 02139, USA
Asif Iqbal Shawl: Department of Biology, College of Arts and Sciences, Main Campus, Khalifa University, Abu Dhabi P.O. Box 127788, United Arab Emirates
Syed Salman Ashraf: Department of Biology, College of Arts and Sciences, Main Campus, Khalifa University, Abu Dhabi P.O. Box 127788, United Arab Emirates
Huseyin Avci: Department of Metallurgical and Materials Engineering, Eskisehir Osmangazi University, 26040 Eskisehir, Turkey
Shabir Hassan: Division of Engineering in Medicine, Brigham and Women’s Hospital, Department of Medicine, Harvard Medical School, Cambridge, MA 02139, USA

DOI: https://doi.org/10.3390/pharmaceutics14102244
Journal volume & issue: Vol. 14, no. 10
p. 2244

Abstract

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Non-targeted persistent immune activation or suppression by different drug delivery platforms can cause adverse and chronic physiological effects including cancer and arthritis. Therefore, non-toxic materials that do not trigger an immunogenic response during delivery are crucial for safe and effective in vivo treatment. Hydrogels are excellent candidates that can be engineered to control immune responses by modulating biomolecule release/adsorption, improving regeneration of lymphoid tissues, and enhancing function during antigen presentation. This review discusses the aspects of hydrogel-based systems used as drug delivery platforms for various diseases. A detailed investigation on different immunomodulation strategies for various delivery options and deliberate upon the outlook of such drug delivery platforms are conducted.

Published in Pharmaceutics

ISSN: 1999-4923 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Pharmacy and materia medica
Website: http://www.mdpi.com/journal/pharmaceutics/

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