mBio (Oct 2021)
Endothelial Heparan Sulfate Mediates Hepatic Neutrophil Trafficking and Injury during Staphylococcus aureus Sepsis
- Gregory J. Golden,
- Alejandro Gómez Toledo,
- Alex Marki,
- James T. Sorrentino,
- Claire Morris,
- Raquel J. Riley,
- Charlotte Spliid,
- Qiongyu Chen,
- Ingrid Cornax,
- Nathan E. Lewis,
- Nissi Varki,
- Dzung Le,
- Johan Malmström,
- Christofer Karlsson,
- Klaus Ley,
- Victor Nizet,
- Jeffrey D. Esko
Affiliations
- Gregory J. Golden
- Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California, USA
- Alejandro Gómez Toledo
- Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California, USA
- Alex Marki
- La Jolla Institute for Allergy and Immunology, San Diego, California, USA
- James T. Sorrentino
- Department of Bioengineering, University of California, San Diego, La Jolla, California, USA
- Claire Morris
- Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California, USA
- Raquel J. Riley
- Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California, USA
- Charlotte Spliid
- Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California, USA
- Qiongyu Chen
- Department of Pathology, University of California, San Diego, La Jolla, California, USA
- Ingrid Cornax
- Department of Pediatrics, University of California, San Diego, La Jolla, California, USA
- Nathan E. Lewis
- Department of Pediatrics, University of California, San Diego, La Jolla, California, USA
- Nissi Varki
- Department of Pathology, University of California, San Diego, La Jolla, California, USA
- Dzung Le
- Department of Pathology, University of California, San Diego, La Jolla, California, USA
- Johan Malmström
- Department of Clinical Sciences, Division of Infection Medicine, Lund University, Lund, Sweden
- Christofer Karlsson
- Department of Clinical Sciences, Division of Infection Medicine, Lund University, Lund, Sweden
- Klaus Ley
- La Jolla Institute for Allergy and Immunology, San Diego, California, USA
- Victor Nizet
- Department of Pediatrics, University of California, San Diego, La Jolla, California, USA
- Jeffrey D. Esko
- ORCiD
- Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California, USA
- DOI
- https://doi.org/10.1128/mBio.01181-21
- Journal volume & issue
-
Vol. 12,
no. 5
Abstract
Vascular glycocalyx remodeling is critical to sepsis pathology, but the glycocalyx components that contribute to this process remain poorly characterized. This article shows that during Staphylococcus aureus
