Frontiers in Immunology (Sep 2018)
Taurodeoxycholate Increases the Number of Myeloid-Derived Suppressor Cells That Ameliorate Sepsis in Mice
- Sooghee Chang,
- Youn-Hee Kim,
- Youn-Hee Kim,
- Young-Joo Kim,
- Young-Joo Kim,
- Young-Woo Kim,
- Young-Woo Kim,
- Sungyoon Moon,
- Yong Yook Lee,
- Jin Sun Jung,
- Youngsoo Kim,
- Hi-Eun Jung,
- Tae-Joo Kim,
- Taek-Chin Cheong,
- Hye-Jung Moon,
- Jung-Ah Cho,
- Jung-Ah Cho,
- Hang-Rae Kim,
- Hang-Rae Kim,
- Dohyun Han,
- Yirang Na,
- Yirang Na,
- Seung-Hyeok Seok,
- Seung-Hyeok Seok,
- Nam-Hyuk Cho,
- Nam-Hyuk Cho,
- Nam-Hyuk Cho,
- Hai-Chon Lee,
- Eun-Hee Nam,
- Hyosuk Cho,
- Murim Choi,
- Nagahiro Minato,
- Seung-Yong Seong,
- Seung-Yong Seong,
- Seung-Yong Seong
Affiliations
- Sooghee Chang
- Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, South Korea
- Youn-Hee Kim
- Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, South Korea
- Youn-Hee Kim
- Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea
- Young-Joo Kim
- Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, South Korea
- Young-Joo Kim
- Wide River Institute of Immunology, Seoul National University, Seoul, South Korea
- Young-Woo Kim
- Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea
- Young-Woo Kim
- Wide River Institute of Immunology, Seoul National University, Seoul, South Korea
- Sungyoon Moon
- Wide River Institute of Immunology, Seoul National University, Seoul, South Korea
- Yong Yook Lee
- Wide River Institute of Immunology, Seoul National University, Seoul, South Korea
- Jin Sun Jung
- Wide River Institute of Immunology, Seoul National University, Seoul, South Korea
- Youngsoo Kim
- Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea
- Hi-Eun Jung
- Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea
- Tae-Joo Kim
- Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea
- Taek-Chin Cheong
- Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea
- Hye-Jung Moon
- Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, South Korea
- Jung-Ah Cho
- Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, South Korea
- Jung-Ah Cho
- Wide River Institute of Immunology, Seoul National University, Seoul, South Korea
- Hang-Rae Kim
- Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea
- Hang-Rae Kim
- Department of Anatomy, Seoul National University College of Medicine, Seoul, South Korea
- Dohyun Han
- Biomedical Research Institute, Seoul National University Hospital, Seoul, South Korea
- Yirang Na
- Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, South Korea
- Yirang Na
- Biomedical Research Institute, Seoul National University Hospital, Seoul, South Korea
- Seung-Hyeok Seok
- Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, South Korea
- Seung-Hyeok Seok
- Biomedical Research Institute, Seoul National University Hospital, Seoul, South Korea
- Nam-Hyuk Cho
- Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, South Korea
- Nam-Hyuk Cho
- Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea
- Nam-Hyuk Cho
- Wide River Institute of Immunology, Seoul National University, Seoul, South Korea
- Hai-Chon Lee
- Wide River Institute of Immunology, Seoul National University, Seoul, South Korea
- Eun-Hee Nam
- Wide River Institute of Immunology, Seoul National University, Seoul, South Korea
- Hyosuk Cho
- Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea
- Murim Choi
- Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea
- Nagahiro Minato
- Department of Immunology and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
- Seung-Yong Seong
- Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, South Korea
- Seung-Yong Seong
- Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea
- Seung-Yong Seong
- Wide River Institute of Immunology, Seoul National University, Seoul, South Korea
- DOI
- https://doi.org/10.3389/fimmu.2018.01984
- Journal volume & issue
-
Vol. 9
Abstract
Bile acids (BAs) control metabolism and inflammation by interacting with several receptors. Here, we report that intravenous infusion of taurodeoxycholate (TDCA) decreases serum pro-inflammatory cytokines, normalizes hypotension, protects against renal injury, and prolongs mouse survival during sepsis. TDCA increases the number of granulocytic myeloid-derived suppressor cells (MDSCLT) distinctive from MDSCs obtained without TDCA treatment (MDSCL) in the spleen of septic mice. FACS-sorted MDSCLT cells suppress T-cell proliferation and confer protection against sepsis when adoptively transferred better than MDSCL. Proteogenomic analysis indicated that TDCA controls chromatin silencing, alternative splicing, and translation of the immune proteome of MDSCLT, which increases the expression of anti-inflammatory molecules such as oncostatin, lactoferrin and CD244. TDCA also decreases the expression of pro-inflammatory molecules such as neutrophil elastase. These findings suggest that TDCA globally edits the proteome to increase the number of MDSCLT cells and affect their immune-regulatory functions to resolve systemic inflammation during sepsis.
Keywords
