Frontiers in Pharmacology (Feb 2023)
Insights into bone morphogenetic proteins in cardiovascular diseases
- Di Ye,
- Di Ye,
- Di Ye,
- Yinghui Liu,
- Heng Pan,
- Heng Pan,
- Heng Pan,
- Yongqi Feng,
- Yongqi Feng,
- Yongqi Feng,
- Xiyi Lu,
- Xiyi Lu,
- Xiyi Lu,
- Liren Gan,
- Liren Gan,
- Liren Gan,
- Jun Wan,
- Jun Wan,
- Jun Wan,
- Jing Ye,
- Jing Ye,
- Jing Ye
Affiliations
- Di Ye
- Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
- Di Ye
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Di Ye
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Yinghui Liu
- Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China
- Heng Pan
- Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
- Heng Pan
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Heng Pan
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Yongqi Feng
- Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
- Yongqi Feng
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Yongqi Feng
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Xiyi Lu
- Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
- Xiyi Lu
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Xiyi Lu
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Liren Gan
- Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
- Liren Gan
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Liren Gan
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Jun Wan
- Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
- Jun Wan
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Jun Wan
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Jing Ye
- Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
- Jing Ye
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Jing Ye
- Hubei Key Laboratory of Cardiology, Wuhan, China
- DOI
- https://doi.org/10.3389/fphar.2023.1125642
- Journal volume & issue
-
Vol. 14
Abstract
Bone morphogenetic proteins (BMPs) are secretory proteins belonging to the transforming growth factor-β (TGF-β) superfamily. These proteins play important roles in embryogenesis, bone morphogenesis, blood vessel remodeling and the development of various organs. In recent years, as research has progressed, BMPs have been found to be closely related to cardiovascular diseases, especially atherosclerosis, vascular calcification, cardiac remodeling, pulmonary arterial hypertension (PAH) and hereditary hemorrhagic telangiectasia (HHT). In this review, we summarized the potential roles and related mechanisms of the BMP family in the cardiovascular system and focused on atherosclerosis and PAH.
Keywords
