Membrane phospholipid synthesis and endoplasmic reticulum function

Abstract

This review presents an overview of mammalian phospholipid synthesis and the cellular locations of the biochemical activities that produce membrane lipid molecular species. The generalized endoplasmic reticulum compartment is a central site for membrane lipid biogenesis, and examples of the emerging relationships between alterations in lipid composition, regulation of membrane lipid biogenesis, and cellular secretory function are discussed.

Keywords

• phospholipids
• sphingolipids
• plasmalogens
• unfolded protein response