Vitamin D deficiency in women of reproductive age, options for correction

Abstract

Vitamin D deficiency is the pandemica for real in the modern world [1]. The role of vitamin D in the reproductive function regulation has been proven in light of the achievements over the past few years. Being a steroid hormone, this vitamin is essential for a wide range of normal physiologic functions. Vitamin D insufficiency as defined by serum 25(OH)D ≤ 30 ng/ml is widespread globally, with the frequency of registration of this condition among the population of Russia over 90% [2]. The elderly and pregnant women (especially in the presence of fat metabolism disorders, gestational diabetes and infectious pathology), who did not undergo a vitamin correction medication, is the main risk group for vitamin D deficiency. Objective of the study: Evaluate the efficacy of colcalciferol in vitamin D-deficient therapy in women of reproductive age. Material and methods of the study: clinical and laboratory examination and treatment of 31 patients with various reproductive system pathologies, aged 21 to 45 years who were hospitalized to the Department of Gynaecology. In addition to the general clinical examination, all patients had their vitamin D, total and ionized calcium levels in blood plasma assessed. In order to correct the vitamin D deficiency and insufficiency, the vitamin D supplementation by colcalciferol (vitamin D3) intake was prescribed to all examined patients in addition to the treatment of the underlying disease. Results of the study: all examined patients showed the decreased vitamin D concentration in the blood plasma below the reference indices. The vitamin D deficiency was discovered in 64.5% cases. At the same time, a significant increase in the concentration of 25(OH)D3 in blood plasma was noted against the background of therapy.

Keywords

• vitamin d deficiency
• colcalciferol