Metabolic adaptability in metastatic breast cancer by AKR1B10-dependent balancing of glycolysis and fatty acid oxidation

Antoinette van Weverwijk; Nikolaos Koundouros; Marjan Iravani; Matthew Ashenden; Qiong Gao; George Poulogiannis; Ute Jungwirth; Clare M. Isacke

doi:10.1038/s41467-019-10592-4

Nature Communications (Jun 2019)

Metabolic adaptability in metastatic breast cancer by AKR1B10-dependent balancing of glycolysis and fatty acid oxidation

Antoinette van Weverwijk,
Nikolaos Koundouros,
Marjan Iravani,
Matthew Ashenden,
Qiong Gao,
George Poulogiannis,
Ute Jungwirth,
Clare M. Isacke

Affiliations

Antoinette van Weverwijk: The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research
Nikolaos Koundouros: Department of Cancer Biology, The Institute of Cancer Research
Marjan Iravani: The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research
Matthew Ashenden: The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research
Qiong Gao: The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research
George Poulogiannis: Department of Cancer Biology, The Institute of Cancer Research
Ute Jungwirth: The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research
Clare M. Isacke: The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research

DOI: https://doi.org/10.1038/s41467-019-10592-4
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

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Cancer cells must develop distinct metabolic adaptations to survive in challenging metastatic environments. Here, the authors find, via an in vivo RNAi screen, that the aldo-keto reductase AKR1B10 limits the toxic side effects of oxidative stress to sustain fatty acid oxidation and promote metastatic colonisation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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