Nature Communications (Oct 2016)
A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome
- Rasika Ann Mathias,
- Margaret A. Taub,
- Christopher R. Gignoux,
- Wenqing Fu,
- Shaila Musharoff,
- Timothy D. O'Connor,
- Candelaria Vergara,
- Dara G. Torgerson,
- Maria Pino-Yanes,
- Suyash S. Shringarpure,
- Lili Huang,
- Nicholas Rafaels,
- Meher Preethi Boorgula,
- Henry Richard Johnston,
- Victor E. Ortega,
- Albert M. Levin,
- Wei Song,
- Raul Torres,
- Badri Padhukasahasram,
- Celeste Eng,
- Delmy-Aracely Mejia-Mejia,
- Trevor Ferguson,
- Zhaohui S. Qin,
- Alan F. Scott,
- Maria Yazdanbakhsh,
- James G. Wilson,
- Javier Marrugo,
- Leslie A. Lange,
- Rajesh Kumar,
- Pedro C. Avila,
- L. Keoki Williams,
- Harold Watson,
- Lorraine B. Ware,
- Christopher Olopade,
- Olufunmilayo Olopade,
- Ricardo Oliveira,
- Carole Ober,
- Dan L. Nicolae,
- Deborah Meyers,
- Alvaro Mayorga,
- Jennifer Knight-Madden,
- Tina Hartert,
- Nadia N. Hansel,
- Marilyn G. Foreman,
- Jean G. Ford,
- Mezbah U. Faruque,
- Georgia M. Dunston,
- Luis Caraballo,
- Esteban G. Burchard,
- Eugene Bleecker,
- Maria Ilma Araujo,
- Edwin Francisco Herrera-Paz,
- Kimberly Gietzen,
- Wendy E. Grus,
- Michael Bamshad,
- Carlos D. Bustamante,
- Eimear E. Kenny,
- Ryan D. Hernandez,
- Terri H. Beaty,
- Ingo Ruczinski,
- Joshua Akey,
- CAAPA,
- Kathleen C. Barnes
Affiliations
- Rasika Ann Mathias
- Department of Medicine, Johns Hopkins University
- Margaret A. Taub
- Department of Biostatistics, Bloomberg School of Public Health, JHU
- Christopher R. Gignoux
- Department of Genetics, Stanford University School of Medicine
- Wenqing Fu
- Department of Genomic Sciences, University of Washington
- Shaila Musharoff
- Department of Genetics, Stanford University School of Medicine
- Timothy D. O'Connor
- Institute for Genome Sciences, University of Maryland School of Medicine
- Candelaria Vergara
- Department of Medicine, Johns Hopkins University
- Dara G. Torgerson
- Department of Medicine, University of California, San Francisco
- Maria Pino-Yanes
- Department of Medicine, University of California, San Francisco
- Suyash S. Shringarpure
- Department of Genetics, Stanford University School of Medicine
- Lili Huang
- Department of Medicine, Johns Hopkins University
- Nicholas Rafaels
- Department of Medicine, Johns Hopkins University
- Meher Preethi Boorgula
- Department of Medicine, Johns Hopkins University
- Henry Richard Johnston
- Department of Biostatistics and Bioinformatics, Emory University
- Victor E. Ortega
- Center for Human Genomics and Personalized Medicine, Wake Forest School of Medicine
- Albert M. Levin
- Department of Public Health Sciences, Henry Ford Health System
- Wei Song
- Institute for Genome Sciences, University of Maryland School of Medicine
- Raul Torres
- Biomedical Sciences Graduate Program, University of California, San Francisco
- Badri Padhukasahasram
- Center for Health Policy and Health Services Research, Henry Ford Health System
- Celeste Eng
- Department of Medicine, University of California, San Francisco
- Delmy-Aracely Mejia-Mejia
- Centro de Neumologia y Alergias
- Trevor Ferguson
- Tropical Medicine Research Institute, The University of the West Indies
- Zhaohui S. Qin
- Department of Biostatistics and Bioinformatics, Emory University
- Alan F. Scott
- Department of Medicine, Johns Hopkins University
- Maria Yazdanbakhsh
- Department of Parasitology, Leiden University Medical Center
- James G. Wilson
- Department of Physiology and Biophysics, University of Mississippi Medical Center
- Javier Marrugo
- Instituto de Investigaciones Immunologicas, Universidad de Cartagena
- Leslie A. Lange
- Department of Genetics, University of North Carolina
- Rajesh Kumar
- Department of Pediatrics, Northwestern University
- Pedro C. Avila
- Department of Medicine, Northwestern University
- L. Keoki Williams
- Center for Health Policy and Health Services Research, Henry Ford Health System
- Harold Watson
- Faculty of Medical Sciences Cave Hill Campus, The University of the West Indies
- Lorraine B. Ware
- Department of Medicine, Vanderbilt University
- Christopher Olopade
- Department of Medicine and Center for Global Health, University of Chicago
- Olufunmilayo Olopade
- Department of Medicine, University of Chicago
- Ricardo Oliveira
- Laboratório de Patologia Experimental, Centro de Pesquisas Gonçalo Moniz
- Carole Ober
- Department of Human Genetics, University of Chicago
- Dan L. Nicolae
- Department of Medicine, University of Chicago
- Deborah Meyers
- Center for Human Genomics and Personalized Medicine, Wake Forest School of Medicine
- Alvaro Mayorga
- Centro de Neumologia y Alergias
- Jennifer Knight-Madden
- Tropical Medicine Research Institute, The University of the West Indies
- Tina Hartert
- Department of Medicine, Vanderbilt University
- Nadia N. Hansel
- Department of Medicine, Johns Hopkins University
- Marilyn G. Foreman
- Pulmonary and Critical Care Medicine, Morehouse School of Medicine
- Jean G. Ford
- Department of Epidemiology, Bloomberg School of Public Health, JHU
- Mezbah U. Faruque
- National Human Genome Center, Howard University College of Medicine
- Georgia M. Dunston
- National Human Genome Center, Howard University College of Medicine
- Luis Caraballo
- Institute for Immunological Research, Universidad de Cartagena
- Esteban G. Burchard
- Department of Medicine, University of California, San Francisco
- Eugene Bleecker
- Center for Human Genomics and Personalized Medicine, Wake Forest School of Medicine
- Maria Ilma Araujo
- Immunology Service, Universidade Federal da Bahia
- Edwin Francisco Herrera-Paz
- Centro de Neumologia y Alergias
- Kimberly Gietzen
- Illumina, Inc.
- Wendy E. Grus
- Knome Inc.
- Michael Bamshad
- Department of Pediatrics, University of Washington
- Carlos D. Bustamante
- Department of Genetics, Stanford University School of Medicine
- Eimear E. Kenny
- Department of Genetics, Stanford University School of Medicine
- Ryan D. Hernandez
- Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco
- Terri H. Beaty
- Department of Epidemiology, Bloomberg School of Public Health, JHU
- Ingo Ruczinski
- Department of Biostatistics, Bloomberg School of Public Health, JHU
- Joshua Akey
- Department of Genomic Sciences, University of Washington
- CAAPA
- Kathleen C. Barnes
- Department of Medicine, Johns Hopkins University
- DOI
- https://doi.org/10.1038/ncomms12522
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 10
Abstract
The Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA) aims to better understand population genetics of the African diaspora. Here, it uses deeply sequenced whole-genomes to describe the impact of admixture and potential disease burden of deleterious variants.
