Chronic-Relapsing cutaneous leukocytoclastic vasculitis in a young patient with reduced EBV-specific T cell response using enzyme-linked immunospot (ELISPOT) assay successfully treated with Valaciclovir

Caterina Foti; Elvira Favoino; Maria Scarasciulli; Anna Maria Colacicco; Hamidreza Jahantigh; Angela Stufano; Piero Lovreglio; Paola Mascia; Chiara Barlusconi; Federico Perosa; Paolo Romita; Agata Calvario

IDCases (Jan 2021)

Chronic-Relapsing cutaneous leukocytoclastic vasculitis in a young patient with reduced EBV-specific T cell response using enzyme-linked immunospot (ELISPOT) assay successfully treated with Valaciclovir

Caterina Foti,
Elvira Favoino,
Maria Scarasciulli,
Anna Maria Colacicco,
Hamidreza Jahantigh,
Angela Stufano,
Piero Lovreglio,
Paola Mascia,
Chiara Barlusconi,
Federico Perosa,
Paolo Romita,
Agata Calvario

Affiliations

Caterina Foti: Department of Biomedical Science and Human Oncology, Dermatological Clinic, University of Bari “Aldo Moro”, Bari, Italy; Corresponding author.
Elvira Favoino: Department of Biomedical Science and Human Oncology (DIMO), Rheumatic and Systemic Autoimmune Diseases Unit, University of Bari Medical School, Bari, Italy
Maria Scarasciulli: Microbiology and Virology Unit - Interdisciplinary Department of Medicine (DIM) - University of Bari ''Aldo Moro''- AOU Policlinico Bari, Italy
Anna Maria Colacicco: Microbiology and Virology Unit - Interdisciplinary Department of Medicine (DIM) - University of Bari ''Aldo Moro''- AOU Policlinico Bari, Italy
Hamidreza Jahantigh: Interdisciplinary Department of Medicine, University of Bari ''Aldo Moro'', 70124 Bari, Italy
Angela Stufano: Interdisciplinary Department of Medicine, University of Bari ''Aldo Moro'', 70124 Bari, Italy
Piero Lovreglio: Interdisciplinary Department of Medicine, University of Bari ''Aldo Moro'', 70124 Bari, Italy
Paola Mascia: Department of Biomedical Science and Human Oncology, Dermatological Clinic, University of Bari “Aldo Moro”, Bari, Italy
Chiara Barlusconi: Department of Biomedical Science and Human Oncology, Dermatological Clinic, University of Bari “Aldo Moro”, Bari, Italy
Federico Perosa: Department of Biomedical Science and Human Oncology (DIMO), Rheumatic and Systemic Autoimmune Diseases Unit, University of Bari Medical School, Bari, Italy
Paolo Romita: Department of Biomedical Science and Human Oncology, Dermatological Clinic, University of Bari “Aldo Moro”, Bari, Italy
Agata Calvario: Microbiology and Virology Unit - Interdisciplinary Department of Medicine (DIM) - University of Bari ''Aldo Moro''- AOU Policlinico Bari, Italy

Journal volume & issue: Vol. 26
p. e01331

Abstract

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Among different pathogens, opportunistic viral infection caused by EBV is particularly relevant. This gammaherpesvirus, belonging to the Herpesviridae family, may complicate the disease course in different clinical settings by inducing pathological EBV pictures in patients with a defective immunologic response. Our report evaluated EBV-specific T cell responses by IFN- γ ELISPOT assay, which revealed defective EBV specific immunological response.

Published in IDCases

ISSN: 2214-2509 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases
Website: http://www.journals.elsevier.com/idcases/

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