Chemical Modification of Chitosan for Efficient Vaccine Delivery

Lei Xing; Ya-Tong Fan; Tian-Jiao Zhou; Jia-Hui Gong; Lian-Hua Cui; Ki-Hyun Cho; Yun-Jaie Choi; Hu-Lin Jiang; Chong-Su Cho

doi:10.3390/molecules23020229

Molecules (Jan 2018)

Chemical Modification of Chitosan for Efficient Vaccine Delivery

Lei Xing,
Ya-Tong Fan,
Tian-Jiao Zhou,
Jia-Hui Gong,
Lian-Hua Cui,
Ki-Hyun Cho,
Yun-Jaie Choi,
Hu-Lin Jiang,
Chong-Su Cho

Affiliations

Lei Xing: State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China
Ya-Tong Fan: State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China
Tian-Jiao Zhou: State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China
Jia-Hui Gong: State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China
Lian-Hua Cui: Department of Animal Science, College of Agriculture Science, Yanbian University, Yanji, Jilin 133002, China
Ki-Hyun Cho: Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea
Yun-Jaie Choi: Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea
Hu-Lin Jiang: State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China
Chong-Su Cho: Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea

DOI: https://doi.org/10.3390/molecules23020229
Journal volume & issue: Vol. 23, no. 2
p. 229

Abstract

Read online

Chitosan, which exhibits good biocompatibility, safety, microbial degradation and other excellent performances, has found application in all walks of life. In the field of medicine, usage of chitosan for the delivery of vaccine is favored by a wide range of researchers. However, due to its own natural limitations, its application has been constrained to the beginning of study. In order to improve the applicability for vaccine delivery, researchers have carried out various chemical modifications of chitosan. This review summarizes a variety of modification methods and applications of chitosan and its derivatives in the field of vaccine delivery.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

About the journal

Abstract

Keywords