Drimane-Type Sesquiterpenoids Derived from the Tropical Basidiomycetes Perenniporia centrali-africana and Cerrena sp. nov

Paomephan Pathompong; Sebastian Pfütze; Frank Surup; Thitiya Boonpratuang; Rattaket Choeyklin; Josphat C. Matasyoh; Cony Decock; Marc Stadler; Chuenchit Boonchird

doi:10.3390/molecules27185968

Molecules (Sep 2022)

Drimane-Type Sesquiterpenoids Derived from the Tropical Basidiomycetes Perenniporia centrali-africana and Cerrena sp. nov

Paomephan Pathompong,
Sebastian Pfütze,
Frank Surup,
Thitiya Boonpratuang,
Rattaket Choeyklin,
Josphat C. Matasyoh,
Cony Decock,
Marc Stadler,
Chuenchit Boonchird

Affiliations

Paomephan Pathompong: Department of Biotechnology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
Sebastian Pfütze: Department of Microbial Drugs, Helmholtz Centre for Infection Research (HZI), German Centre for Infection Research (DZIF), Partner Site Hannover/Braunschweig, Inhoffenstrasse 7, 38124 Braunschweig, Germany
Frank Surup: Department of Microbial Drugs, Helmholtz Centre for Infection Research (HZI), German Centre for Infection Research (DZIF), Partner Site Hannover/Braunschweig, Inhoffenstrasse 7, 38124 Braunschweig, Germany
Thitiya Boonpratuang: National Biobank of Thailand (NBT), The National Science and Technology for Development Agency (NSTDA), Thailand Science Park, Pathum Thani 12120, Thailand
Rattaket Choeyklin: National Biobank of Thailand (NBT), The National Science and Technology for Development Agency (NSTDA), Thailand Science Park, Pathum Thani 12120, Thailand
Josphat C. Matasyoh: Department of Chemistry, Egerton University, P.O. Box 536, Njoro 20115, Kenya
Cony Decock: Earth and Life Institute, Mycothéque de l’ Universite Catholique de Louvain (BCCM/MUCL), Place Croix du Sud 3, B-1348 Louvain-la-Neuve, Belgium
Marc Stadler: Department of Microbial Drugs, Helmholtz Centre for Infection Research (HZI), German Centre for Infection Research (DZIF), Partner Site Hannover/Braunschweig, Inhoffenstrasse 7, 38124 Braunschweig, Germany
Chuenchit Boonchird: Department of Biotechnology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand

DOI: https://doi.org/10.3390/molecules27185968
Journal volume & issue: Vol. 27, no. 18
p. 5968

Abstract

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Five new drimane-type sesquiterpenoids were isolated from cultures of the tropical basidiomycetes, Perenniporia centrali-africana (originating from Kenya) and Cerrena sp. nov. (originating from Thailand). A new pereniporin A derivative (1), a new drimane-type sesquiterpene lactam (2), and the new 6,7-Dehydro-isodrimenediol (3) were isolated from P. centrali-africana. In parallel, the two new drimane-type sesquiterpene lactams 5 and 6 were isolated together with known isodrimenediol (4) from Cerrena sp. This is the first report of drimane-type sesquiterpene lactams from basidiomycetes. The structures were elucidated based on 1D and 2D nuclear magnetic resonance (NMR) spectroscopic data, in combination with high-resolution electrospray mass spectrometric (HR-ESIMS) data. The compounds were devoid of significant antimicrobial and cytotoxic activities.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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