Nature Communications (Aug 2020)
Cardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure
- Toshihiro Yamaguchi,
- Tomokazu S. Sumida,
- Seitaro Nomura,
- Masahiro Satoh,
- Tomoaki Higo,
- Masamichi Ito,
- Toshiyuki Ko,
- Kanna Fujita,
- Mary E. Sweet,
- Atsushi Sanbe,
- Kenji Yoshimi,
- Ichiro Manabe,
- Toshikuni Sasaoka,
- Matthew R. G. Taylor,
- Haruhiro Toko,
- Eiki Takimoto,
- Atsuhiko T. Naito,
- Issei Komuro
Affiliations
- Toshihiro Yamaguchi
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Tomokazu S. Sumida
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Seitaro Nomura
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Masahiro Satoh
- Genome Science Division, Research Center for Advanced Science and Technologies, The University of Tokyo
- Tomoaki Higo
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
- Masamichi Ito
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Toshiyuki Ko
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Kanna Fujita
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Mary E. Sweet
- Human Medical Genetics and Genomics, University of Colorado
- Atsushi Sanbe
- Department of Pharmacotherapeutics, School of Pharmacy, Iwate Medical University
- Kenji Yoshimi
- Department of Neurophysiology, Juntendo University Graduate School of Medicine
- Ichiro Manabe
- Department of Disease Biology and Molecular Medicine, Graduate School of Medicine, Chiba University
- Toshikuni Sasaoka
- Department of Comparative and Experimental Medicine, Brain Research Institute, Niigata University
- Matthew R. G. Taylor
- Human Medical Genetics and Genomics, University of Colorado
- Haruhiro Toko
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Eiki Takimoto
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Atsuhiko T. Naito
- Department of Physiology, Faculty of Medicine, Toho University
- Issei Komuro
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- DOI
- https://doi.org/10.1038/s41467-020-18128-x
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 8
Abstract
The pathophysiological role of dopamine D1 receptor (D1R) in chronic heart failure remains elusive. Here the authors show that D1R-expressing cardiomyocytes appear in chronic heart failure and play a pivotal role in triggering lethal ventricular arrhythmias.
