Artificial Cells, Nanomedicine, and Biotechnology (Dec 2019)

Associations between IL-23R gene polymorphisms and the susceptibility of rheumatoid arthritis: a meta-analysis

  • Qinghua Zou,
  • Yi Zhao,
  • Yong Wang,
  • Yongfei Fang,
  • Yi Liu

DOI
https://doi.org/10.1080/21691401.2019.1579731
Journal volume & issue
Vol. 47, no. 1
pp. 951 – 956

Abstract

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Objective This meta-analysis was aimed to verify the influences of interleukin 23 receptor (IL-23R) rs11209026 and rs2201841 polymorphisms on the susceptibility of rheumatoid arthritis (RA).Methods We searched potentially relevant studies on the relationships of IL-23R gene rs11209026 and rs2201841 polymorphisms with RA susceptibility from PubMed (Medline), CNKI and EMBASE web databases. Crude odds ratios (ORs) along with 95% confidence intervals (95% CIs) were calculated to assess the strength of association through the fixed- or random-effects model.Results Eight published articles containing 5544 RA patients and 5532 health individuals were included in our meta-analysis. In total analysis, we found IL-23R gene rs11209026 polymorphism was not related to RA susceptibility in all genetic models, but there was a significant association between rs2201841 polymorphism and RA susceptibility under G vs. A model. In stratified analysis by ethnicity, an increased RA susceptibility was detected for rs2201841 polymorphism in Caucasian group.Conclusion The results of meta-analysis indicated that IL-23R gene rs2201841 polymorphism might be a susceptible factor for RA under G vs. A model, especially in Caucasian population.

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