Nature Communications (Nov 2019)
Prefrontal cortical ChAT-VIP interneurons provide local excitation by cholinergic synaptic transmission and control attention
- Joshua Obermayer,
- Antonio Luchicchi,
- Tim S. Heistek,
- Sybren F. de Kloet,
- Huub Terra,
- Bastiaan Bruinsma,
- Ouissame Mnie-Filali,
- Christian Kortleven,
- Anna A. Galakhova,
- Ayoub J. Khalil,
- Tim Kroon,
- Allert J. Jonker,
- Roel de Haan,
- Wilma D. J. van de Berg,
- Natalia A. Goriounova,
- Christiaan P. J. de Kock,
- Tommy Pattij,
- Huibert D. Mansvelder
Affiliations
- Joshua Obermayer
- Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Vrije Universiteit
- Antonio Luchicchi
- Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Vrije Universiteit
- Tim S. Heistek
- Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Vrije Universiteit
- Sybren F. de Kloet
- Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Vrije Universiteit
- Huub Terra
- Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Vrije Universiteit
- Bastiaan Bruinsma
- Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Vrije Universiteit
- Ouissame Mnie-Filali
- Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Vrije Universiteit
- Christian Kortleven
- Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Vrije Universiteit
- Anna A. Galakhova
- Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Vrije Universiteit
- Ayoub J. Khalil
- Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Vrije Universiteit
- Tim Kroon
- Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Vrije Universiteit
- Allert J. Jonker
- Department of Anatomy and Neurosciences, Amsterdam UMC, Vrije Universiteit
- Roel de Haan
- Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Vrije Universiteit
- Wilma D. J. van de Berg
- Department of Anatomy and Neurosciences, Amsterdam UMC, Vrije Universiteit
- Natalia A. Goriounova
- Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Vrije Universiteit
- Christiaan P. J. de Kock
- Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Vrije Universiteit
- Tommy Pattij
- Department of Anatomy and Neurosciences, Amsterdam UMC, Vrije Universiteit
- Huibert D. Mansvelder
- Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Vrije Universiteit
- DOI
- https://doi.org/10.1038/s41467-019-13244-9
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
VIP interneurons have been shown to disinhibit pyramidal neurons by inhibiting other interneuron types. Here, the authors report that ChAT-VIP subtype of interneurons directly excite pyramidal neurons in multiple layers via fast cholinergic neurotransmission.
