Turkish Journal of Colorectal Disease (Dec 2018)
Comparison of the Efficacy of Polyethylene Glycol, Sennoside and Sodium Phosphate in Bowel Preparation Before Colonoscopy
Abstract
Aim: The great majority of colorectal cancers arise from pre-existing adenomatous polyps. High-quality bowel cleansing is essential to improve the quality of colonoscopy. The most important factors in choosing a bowel cleansing agent are efficacy, tolerance, and safety. We aimed to compare the efficacy of polyethylene glycol (PEG), sennoside, and sodium phosphate for bowel cleansing in equally sized groups of patients undergoing colonoscopy at our center. Method: A total of 600 patients undergoing colonoscopy at the University of Health Sciences Haydarpaşa Numune Training and Research Hospital General Surgery Endoscopy Unit the were included in the study irrespective of age, gender, and other factors. The patients were divided into 3 equal groups and were given either 4 liters of PEG solution, 500 mL of sennoside, or 90 mL of sodium phosphate solution for bowel preparation. The adequacy of bowel preparation was assessed using the Boston Bowel Preparation Scale and the results were compared. Results: The polyp detection rate was higher in the PEG group than in the sennoside group, and lower in the sodium phosphate group compared to both the PEG and sennoside groups. Bowel preparation scores were similar in the PEG and sennoside groups but lower in the sodium phosphate group compared to the other two groups. Conclusion: There was no difference in the quality of bowel preparation in patients who used PEG solution and sennosides; however, we observed a difference in polyp detection rates between these groups. This difference may be attributable to other factors that affect polyp detection (cecal intubation status, withdrawal time, technical difficulties, endoscopist experience). The lower polyp detection rate among patients using sodium phosphate seems to be a result of these factors combined with inadequate bowel cleansing. Socio-demographic features of the study population also affect colonoscopy outcomes.
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