P1.05 ASSESSMENT OF ARTERIAL STIFFNESS IN HYPERTENSION: COMPARISON OF OSCILLOMETRIC (ARTERIOGRAPH), PIEZO-ELECTRONIC (COMPLIOR), AND TONOMETRIC (SPHYGMOCOR) TECHNIQUES

Abstract

Arterial stiffness, measured as aortic pulse wave velocity (PWV), and wave reflection, measured as augmentation index (AIx) are independent predictors, for total and cardiovascular morbidity and mortality. The aim of this study was to compare a new device, based on oscillometric pressure curves (Arteriograph) which simultaneously measures PWV and AIx to standard techniques for measuring PWV (Complior) and AIx (SphygmoCor) in untreated hypertensive subjects. We compared PWV and AIx measured using the Arteriograph with corresponding Complior and SphygmoCor measurements in 254 untreated hypertensive patients, age 48±14 (mean±SD) [17 to 85 years]. Arteriograph PWV and AIx were closely related with Complior (r=0.60, P<0.001), and SphygmoCor (r=0.89, P<0.001) respectively. Using stepwise regression analysis, the independent determinants of Arteriograph PWV were age, mean arterial pressure (MAP), heart rate (HR) and gender (R2=0.44p<0.0001) and for AIx; age, weight, MAP, HR and gender (R2=0.65, p<0.0001). The bias between the different techniques was determined by age and gender for PWV and age, body weight, gender, HR and MAP for AIx. Bland-Altman Plots showed that while the techniques were closely related, the limits of agreement were wide. While Arteriograph values and the determinants of PWV and AIx are in close agreement with corresponding parameters obtained by Complior and SphygmoCor respectively, the techniques are not interchangeable.