Nature Communications (Oct 2020)
Type 2 and interferon inflammation regulate SARS-CoV-2 entry factor expression in the airway epithelium
- Satria P. Sajuthi,
- Peter DeFord,
- Yingchun Li,
- Nathan D. Jackson,
- Michael T. Montgomery,
- Jamie L. Everman,
- Cydney L. Rios,
- Elmar Pruesse,
- James D. Nolin,
- Elizabeth G. Plender,
- Michael E. Wechsler,
- Angel C. Y. Mak,
- Celeste Eng,
- Sandra Salazar,
- Vivian Medina,
- Eric M. Wohlford,
- Scott Huntsman,
- Deborah A. Nickerson,
- Soren Germer,
- Michael C. Zody,
- Gonçalo Abecasis,
- Hyun Min Kang,
- Kenneth M. Rice,
- Rajesh Kumar,
- Sam Oh,
- Jose Rodriguez-Santana,
- Esteban G. Burchard,
- Max A. Seibold
Affiliations
- Satria P. Sajuthi
- Center for Genes, Environment, and Health, National Jewish Health
- Peter DeFord
- Center for Genes, Environment, and Health, National Jewish Health
- Yingchun Li
- Center for Genes, Environment, and Health, National Jewish Health
- Nathan D. Jackson
- Center for Genes, Environment, and Health, National Jewish Health
- Michael T. Montgomery
- Center for Genes, Environment, and Health, National Jewish Health
- Jamie L. Everman
- Center for Genes, Environment, and Health, National Jewish Health
- Cydney L. Rios
- Center for Genes, Environment, and Health, National Jewish Health
- Elmar Pruesse
- Center for Genes, Environment, and Health, National Jewish Health
- James D. Nolin
- Center for Genes, Environment, and Health, National Jewish Health
- Elizabeth G. Plender
- Center for Genes, Environment, and Health, National Jewish Health
- Michael E. Wechsler
- Department of Medicine, National Jewish Health
- Angel C. Y. Mak
- Department of Medicine, University of California San Francisco
- Celeste Eng
- Department of Medicine, University of California San Francisco
- Sandra Salazar
- Department of Medicine, University of California San Francisco
- Vivian Medina
- Centro de Neumología Pediátrica
- Eric M. Wohlford
- Department of Medicine, University of California San Francisco
- Scott Huntsman
- Department of Medicine, University of California San Francisco
- Deborah A. Nickerson
- Department of Genome Sciences, University of Washington
- Soren Germer
- New York Genome Center
- Michael C. Zody
- New York Genome Center
- Gonçalo Abecasis
- Center for Statistical Genetics, University of Michigan
- Hyun Min Kang
- Center for Statistical Genetics, University of Michigan
- Kenneth M. Rice
- Department of Biostatistics, University of Washington
- Rajesh Kumar
- Department of Pediatrics, Ann and Robert H. Lurie Children’s Hospital of Chicago, Northwestern University
- Sam Oh
- Department of Medicine, University of California San Francisco
- Jose Rodriguez-Santana
- Centro de Neumología Pediátrica
- Esteban G. Burchard
- Department of Medicine, University of California San Francisco
- Max A. Seibold
- Center for Genes, Environment, and Health, National Jewish Health
- DOI
- https://doi.org/10.1038/s41467-020-18781-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 18
Abstract
ACE2 and TMPRSS2 have received recent attention as entry factors for SARS-CoV-2. Here the authors analyze nasal airway transcriptome data from 695 children determining ACE2 and TMPRSS2 expression is induced by viral and type2 inflammation, respectively, and both exhibit eQTLs that vary across world populations.
