Soluble E-cadherin promotes tumor angiogenesis and localizes to exosome surface

Maggie K. S. Tang; Patrick Y. K. Yue; Philip P. Ip; Rui-Lan Huang; Hung-Cheng Lai; Annie N. Y. Cheung; Ka Yu Tse; Hextan Y. S. Ngan; Alice S. T. Wong

doi:10.1038/s41467-018-04695-7

Nature Communications (Jun 2018)

Soluble E-cadherin promotes tumor angiogenesis and localizes to exosome surface

Maggie K. S. Tang,
Patrick Y. K. Yue,
Philip P. Ip,
Rui-Lan Huang,
Hung-Cheng Lai,
Annie N. Y. Cheung,
Ka Yu Tse,
Hextan Y. S. Ngan,
Alice S. T. Wong

Affiliations

Maggie K. S. Tang: School of Biological Sciences, University of Hong Kong
Patrick Y. K. Yue: Department of Biology, Hong Kong Baptist University
Philip P. Ip: Department of Pathology, University of Hong Kong
Rui-Lan Huang: Department of Obstetrics and Gynecology, Shuang-Ho Hospital, Taipei Medical University
Hung-Cheng Lai: Department of Obstetrics and Gynecology, Shuang-Ho Hospital, Taipei Medical University
Annie N. Y. Cheung: Department of Pathology, University of Hong Kong
Ka Yu Tse: Department of Obstetrics and Gynecology, University of Hong Kong
Hextan Y. S. Ngan: Department of Obstetrics and Gynecology, University of Hong Kong
Alice S. T. Wong: School of Biological Sciences, University of Hong Kong

DOI: https://doi.org/10.1038/s41467-018-04695-7
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 15

Abstract

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A soluble form E-cadherin is highly expressed in ovarian cancer. Here, the authors show that soluble E-cadherin is released by ovarian cancer cells packaged in exosomes and promotes tumor angiogenesis through β-catenin and NFkB signaling activation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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