Nature Communications (May 2021)
INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer
- Samuel J. Rodgers,
- Lisa M. Ooms,
- Viola M. J. Oorschot,
- Ralf B. Schittenhelm,
- Elizabeth V. Nguyen,
- Sabryn A. Hamila,
- Natalie Rynkiewicz,
- Rajendra Gurung,
- Matthew J. Eramo,
- Absorn Sriratana,
- Clare G. Fedele,
- Franco Caramia,
- Sherene Loi,
- Genevieve Kerr,
- Helen E. Abud,
- Georg Ramm,
- Antonella Papa,
- Andrew M. Ellisdon,
- Roger J. Daly,
- Catriona A. McLean,
- Christina A. Mitchell
Affiliations
- Samuel J. Rodgers
- Cancer Program, Biomedicine Discovery Institute, Monash University
- Lisa M. Ooms
- Cancer Program, Biomedicine Discovery Institute, Monash University
- Viola M. J. Oorschot
- Monash Ramaciotti Centre for Cryo Electron Microscopy, a Node of Microscopy Australia, Monash University
- Ralf B. Schittenhelm
- Monash Proteomics and Metabolomics Facility, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University
- Elizabeth V. Nguyen
- Cancer Program, Biomedicine Discovery Institute, Monash University
- Sabryn A. Hamila
- Cancer Program, Biomedicine Discovery Institute, Monash University
- Natalie Rynkiewicz
- Department of Biochemistry and Molecular Biology, Monash University
- Rajendra Gurung
- Cancer Program, Biomedicine Discovery Institute, Monash University
- Matthew J. Eramo
- Cancer Program, Biomedicine Discovery Institute, Monash University
- Absorn Sriratana
- Cancer Program, Biomedicine Discovery Institute, Monash University
- Clare G. Fedele
- Department of Biochemistry and Molecular Biology, Monash University
- Franco Caramia
- Peter MacCallum Cancer Centre, University of Melbourne
- Sherene Loi
- Peter MacCallum Cancer Centre, University of Melbourne
- Genevieve Kerr
- Development and Stem Cells Program, Biomedicine Discovery Institute, Monash University
- Helen E. Abud
- Development and Stem Cells Program, Biomedicine Discovery Institute, Monash University
- Georg Ramm
- Cancer Program, Biomedicine Discovery Institute, Monash University
- Antonella Papa
- Cancer Program, Biomedicine Discovery Institute, Monash University
- Andrew M. Ellisdon
- Cancer Program, Biomedicine Discovery Institute, Monash University
- Roger J. Daly
- Cancer Program, Biomedicine Discovery Institute, Monash University
- Catriona A. McLean
- Department of Anatomical Pathology, Alfred Hospital
- Christina A. Mitchell
- Cancer Program, Biomedicine Discovery Institute, Monash University
- DOI
- https://doi.org/10.1038/s41467-021-23241-6
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 19
Abstract
The PI(3,4)P2 4-phosphatase, INPP4B, functions as a tumour suppressor in triple negative breast cancer. Here, the authors show that INPP4B enhances proliferation and growth of PIK3CA-mutant ER+ breast cancers by promoting PI3Kα-dependent late endosome formation and trafficking that leads to the activation of Wnt/β-catenin signalling.
