Comparison of oscillatory activity in subthalamic nucleus in Parkinson's disease and dystonia

Xinyi Geng; Jianguo Zhang; Yin Jiang; Keyoumars Ashkan; Thomas Foltynie; Patricia Limousin; Ludvic Zrinzo; Alexander Green; Tipu Aziz; Peter Brown; Shouyan Wang

Neurobiology of Disease (Feb 2017)

Comparison of oscillatory activity in subthalamic nucleus in Parkinson's disease and dystonia

Xinyi Geng,
Jianguo Zhang,
Yin Jiang,
Keyoumars Ashkan,
Thomas Foltynie,
Patricia Limousin,
Ludvic Zrinzo,
Alexander Green,
Tipu Aziz,
Peter Brown,
Shouyan Wang

Affiliations

Xinyi Geng: Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, 88 Keling Road, SND, Suzhou 215163, China; MRC Brain Network Dynamics Unit, University of Oxford, Mansfield Road, Oxford OX13TH, UK; University of Chinese Academy of Sciences, 19A Yuquan Road, Shijingshan District, Beijing 100049, China
Jianguo Zhang: Department of Neurosurgery, Beijing Tian-Tan Hospital, Beijing Neurosurgical Institute, Capital Medical University, 6 Tiantan West Road, Dongcheng District, Beijing 100050, China
Yin Jiang: Department of Neurosurgery, Beijing Tian-Tan Hospital, Beijing Neurosurgical Institute, Capital Medical University, 6 Tiantan West Road, Dongcheng District, Beijing 100050, China
Keyoumars Ashkan: Institute of Psychiatry, Psychology and Neuroscience, Kings College London, Strand, London WC2R 2LS, UK
Thomas Foltynie: Sobell Department of Motor Neuroscience & Movement Disorders, UCL Institute of Neurology, University College London, Gower Street, London WC1E 6BT, UK
Patricia Limousin: Sobell Department of Motor Neuroscience & Movement Disorders, UCL Institute of Neurology, University College London, Gower Street, London WC1E 6BT, UK
Ludvic Zrinzo: Sobell Department of Motor Neuroscience & Movement Disorders, UCL Institute of Neurology, University College London, Gower Street, London WC1E 6BT, UK
Alexander Green: Nuffield Department of Clinical Neurosciences, University of Oxford, West Wing, John Radcliffe Hospital, Oxford OX39DU, UK
Tipu Aziz: Nuffield Department of Clinical Neurosciences, University of Oxford, West Wing, John Radcliffe Hospital, Oxford OX39DU, UK
Peter Brown: MRC Brain Network Dynamics Unit, University of Oxford, Mansfield Road, Oxford OX13TH, UK
Shouyan Wang: Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, 88 Keling Road, SND, Suzhou 215163, China; Corresponding author at: 88 Keling Road, SND, Suzhou, Jiangsu 215163, China.

Journal volume & issue: Vol. 98
pp. 100 – 107

Abstract

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Objectives: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has been successfully used to treat both Parkinson's disease (PD) and dystonia. Local field potentials (LFPs) recorded from the STN of PD patients demonstrate prominent beta frequency band activity. It is unclear whether such activity occurs in the STN in dystonia, and, if not, whether dystonia has another distinctive neural population activity in the STN. Methods: Twelve patients with PD, and eight patients with dystonia underwent DBS electrode implantation targeting the STN. Seven dystonia patients were off medication and one was on aripiprazole and clonazepam. LFPs were recorded from the DBS electrodes in PD in the on/off medication states and in dystonia. Power spectra and temporal dynamics measured by the with Lempel-Ziv complexity of the LFPs were compared among these states. Results: Normalised power spectra and Lempel-Ziv complexity of subthalamic LFPs differed between dystonia off and PD on/off, and between PD off and on over the low frequency, beta and high gamma bands. Patients with dystonia and off medication had lower beta power but higher low frequency and high gamma power than PD. Spectral power in the low beta frequency (11–20 Hz) range was attenuated in medicated PD. Conclusion: The results suggest that dystonia and PD are characterized by different patterns of oscillatory activities even within the same nucleus, and exaggerated beta activity may relate to hypo-dopaminergic status.

Published in Neurobiology of Disease

ISSN: 0969-9961 (Print); 1095-953X (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/neurobiology-of-disease

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