Mechanical unloading enhances bone destruction and tumor expansion in multiple myeloma: Critical roles of osteocytic RANKL induction

• Kotaro Tanimoto,
• Masahiro Hiasa,
• Hirofumi Tenshin,
• Jumpei Teramachi,
• Asuka Oda,
• Takeshi Harada,
• Mohannad Ashter,
• Kimiko Sogabe,
• Masahiro Oura,
• Itsuro Endo,
• Toshio Matsumoto,
• Eiji Tanaka,
• Masahiro Abe

Affiliations

Kotaro Tanimoto

Department of Orthodontics and Dentofacial Orthopedic, Tokushima University, Tokushima, Japan, Tokushima, Japan; Department of Hematology, Endocrinology and Metabolism, Tokushima University, Tokushima, Japan, Tokushim, Japan; Corresponding author at: Department of Orthodontics and Dentofacial Orthopedic, Tokushima University, Tokushima, Japan, Tokushima, Japan.

Masahiro Hiasa

Department of Orthodontics and Dentofacial Orthopedic, Tokushima University, Tokushima, Japan, Tokushima, Japan; Department of Hematology, Endocrinology and Metabolism, Tokushima University, Tokushima, Japan, Tokushim, Japan

Hirofumi Tenshin

Department of Orthodontics and Dentofacial Orthopedic, Tokushima University, Tokushima, Japan, Tokushima, Japan; Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima Univeersity, Tokushim, Japan

Jumpei Teramachi

Department of Hematology, Endocrinology and Metabolism, Tokushima University, Tokushima, Japan, Tokushim, Japan; Department of Tissue Regeneration, Tokushima University, Tokushima, Japan, Tokushima, Japan

Asuka Oda

Department of Hematology, Endocrinology and Metabolism, Tokushima University, Tokushima, Japan, Tokushim, Japan

Takeshi Harada

Department of Hematology, Endocrinology and Metabolism, Tokushima University, Tokushima, Japan, Tokushim, Japan

Mohannad Ashter

Department of Orthodontics and Dentofacial Orthopedic, Tokushima University, Tokushima, Japan, Tokushima, Japan; Department of Hematology, Endocrinology and Metabolism, Tokushima University, Tokushima, Japan, Tokushim, Japan

Kimiko Sogabe

Department of Hematology, Endocrinology and Metabolism, Tokushima University, Tokushima, Japan, Tokushim, Japan

Masahiro Oura

Department of Hematology, Endocrinology and Metabolism, Tokushima University, Tokushima, Japan, Tokushim, Japan

Itsuro Endo

Department of Hematology, Endocrinology and Metabolism, Tokushima University, Tokushima, Japan, Tokushim, Japan

Toshio Matsumoto

Fujii Memorial Institute of Medical Sciences, Tokushima University, Tokushima, Japan

Eiji Tanaka

Department of Orthodontics and Dentofacial Orthopedic, Tokushima University, Tokushima, Japan, Tokushima, Japan

Masahiro Abe

Department of Hematology, Endocrinology and Metabolism, Tokushima University, Tokushima, Japan, Tokushim, Japan