Giant seminoma case with very small yolk sac and embryo carcinoma components, detected by intensive histopathological examination

Takeo Nakaya, MD; Shuichiro Kobayashi, MD; Satoshi Kitahara, MD; Akira Tanaka, MD; Hiroshi Kamma, MD; Akio Komatsu, MD

doi:10.1016/j.ehpc.2015.10.005

Human Pathology: Case Reports (Sep 2016)

Giant seminoma case with very small yolk sac and embryo carcinoma components, detected by intensive histopathological examination

Takeo Nakaya, MD,
Shuichiro Kobayashi, MD,
Satoshi Kitahara, MD,
Akira Tanaka, MD,
Hiroshi Kamma, MD,
Akio Komatsu, MD

Affiliations

Takeo Nakaya, MD: Department of Pathology, School of Medicine, Kyorin University, Mitaka, Japan
Shuichiro Kobayashi, MD: Department of Urology, Tama Nambu Chiiki Hospital, Tokyo Metropolitan Health and Medical Treatment Corporation, Tama, Japan
Satoshi Kitahara, MD: Department of Urology, Tama Nambu Chiiki Hospital, Tokyo Metropolitan Health and Medical Treatment Corporation, Tama, Japan
Akira Tanaka, MD: Department of Pathology, Jichi Medical University, Shimotsuke, Japan
Hiroshi Kamma, MD: Department of Pathology, School of Medicine, Kyorin University, Mitaka, Japan
Akio Komatsu, MD: Department of Pathology, Tama Nambu Chiiki Hospital, Tokyo Metropolitan Health and Medical Treatment Corporation, Tama, Japan

DOI: https://doi.org/10.1016/j.ehpc.2015.10.005
Journal volume & issue: Vol. 5, no. C
pp. 29 – 33

Abstract

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We experienced the giant seminoma with 18 × 10 × 10 cm sized and about 2.6 kg weight of 25 year old patient. We intensively examined the histological tissue type distributions in this giant seminoma. Most of the tumor consisted of seminoma components. In addition, the tumor included the very small fragments of yolk sac tumor and embryonal carcinoma component at the root part of the seminoma mass. This shows that intensive histological examination may contribute to the finding of other embryonic component of the large seminoma. This may show that leaving the seminoma growing may generate the other embryonic tumor component, not always big enough to find out in a routine procedure, during the growth, in the different way from the original mixed cell germ tumor.

Published in Human Pathology: Case Reports

ISSN: 2214-3300 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Pathology
Website: http://www.journals.elsevier.com/human-pathology-case-reports/

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