The Predictive Value of the Systemic Immune Inflammation Index for one-year Major Adverse Cardiovascular and Cerebrovascular Events in Patients with Coronary Artery Disease

Abstract

Aim:The study aimed to examine and contrast the ability of a systemic immune inflammation index (SII) to predict major adverse cardiovascular and cerebrovascular events (MACCEs) that occurred one year after carotid artery stenting (CAS) in patients with established coronary artery disease (CAD).Methods:The data of 157 patients with CAD who underwent CAS between April 2015 and January 2020 were retrospectively evaluated. Before the index procedure, blood samples were taken and SII values were calculated and analyses were performed. Measurement of the degree of carotid stenosis was performed according to the North American Symptomatic Carotid Endarterectomy Study. The patients were split into two groups based on whether they experienced MACCEs or not.Results:One hundred-fifty seven patients made up the study population, and their average age was 66.9 +/- 8.7 years. Multivariate Cox regression analysis revealed platelet to lymphocyte ratio (PLR) [hazard ratio (HR): 1.006, p=0.033] and SII [HR: 1.000, p=0.027] independently predicted the MACCEs but neutrophil to lymphocyte ratio did not. Compared with other inflammatory parameters evaluated in the study including C-reactive protein, platelets, and PLR, SII had a better and adequate discriminatory performance for MACCEs (area under the curve: 0.762, p<0.001). An SII ≥615 predicted the one-year MACCEs with 81% sensitivity and 63% specificity.Conclusion:High SII may be a helpful diagnostic for CAS patients with CAD who need to be risk-stratified.

Keywords

• coronary artery disease
• carotis artery stenting
• systemic immune inflammation index