Nature Communications (Jun 2017)
Cellular senescence drives age-dependent hepatic steatosis
- Mikolaj Ogrodnik,
- Satomi Miwa,
- Tamar Tchkonia,
- Dina Tiniakos,
- Caroline L. Wilson,
- Albert Lahat,
- Christoper P. Day,
- Alastair Burt,
- Allyson Palmer,
- Quentin M. Anstee,
- Sushma Nagaraja Grellscheid,
- Jan H J. Hoeijmakers,
- Sander Barnhoorn,
- Derek A. Mann,
- Thomas G. Bird,
- Wilbert P. Vermeij,
- James L. Kirkland,
- João F. Passos,
- Thomas von Zglinicki,
- Diana Jurk
Affiliations
- Mikolaj Ogrodnik
- Newcastle University Institute for Ageing, Institute for Cell and Molecular Biosciences, Campus for Ageing and Vitality, Newcastle University
- Satomi Miwa
- Newcastle University Institute for Ageing, Institute for Cell and Molecular Biosciences, Campus for Ageing and Vitality, Newcastle University
- Tamar Tchkonia
- Robert and Arlene Kogod Center on Aging, Mayo Clinic
- Dina Tiniakos
- Institute of Cellular Medicine, Newcastle University
- Caroline L. Wilson
- Institute of Cellular Medicine, Newcastle University
- Albert Lahat
- Department of Biosciences, Durham University
- Christoper P. Day
- Institute of Cellular Medicine, Newcastle University
- Alastair Burt
- Institute of Cellular Medicine, Newcastle University
- Allyson Palmer
- Robert and Arlene Kogod Center on Aging, Mayo Clinic
- Quentin M. Anstee
- Institute of Cellular Medicine, Newcastle University
- Sushma Nagaraja Grellscheid
- Department of Biosciences, Durham University
- Jan H J. Hoeijmakers
- Department of Molecular Genetics, Erasmus University Medical Center
- Sander Barnhoorn
- Department of Molecular Genetics, Erasmus University Medical Center
- Derek A. Mann
- Institute of Cellular Medicine, Newcastle University
- Thomas G. Bird
- MRC Centre for Inflammation Research, The Queen’s Medical Research Institute, University of Edinburgh
- Wilbert P. Vermeij
- Department of Molecular Genetics, Erasmus University Medical Center
- James L. Kirkland
- Robert and Arlene Kogod Center on Aging, Mayo Clinic
- João F. Passos
- Newcastle University Institute for Ageing, Institute for Cell and Molecular Biosciences, Campus for Ageing and Vitality, Newcastle University
- Thomas von Zglinicki
- Newcastle University Institute for Ageing, Institute for Cell and Molecular Biosciences, Campus for Ageing and Vitality, Newcastle University
- Diana Jurk
- Newcastle University Institute for Ageing, Institute for Cell and Molecular Biosciences, Campus for Ageing and Vitality, Newcastle University
- DOI
- https://doi.org/10.1038/ncomms15691
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 12
Abstract
Non-alcoholic fatty liver disease is more common among older individuals. Here, the authors show that senescent cells in the liver promote fat accumulation and steatosis in the liver, and that clearance of senescent cells reduces hepatic steatosis in old, obese or diabetic mice.
