Bio-Orthogonal Chemistry and Reloadable Biomaterial Enable Local Activation of Antibiotic Prodrugs and Enhance Treatments against Staphylococcus aureus Infections

• Magdalena Czuban,
• Sangeetha Srinivasan,
• Nathan A. Yee,
• Edgar Agustin,
• Anna Koliszak,
• Ethan Miller,
• Irfan Khan,
• Ilenis Quinones,
• Hasina Noory,
• Christopher Motola,
• Rudolf Volkmer,
• Mariagrazia Di Luca,
• Andrej Trampuz,
• Maksim Royzen,
• Jose M. Mejia Oneto

Affiliations

Magdalena Czuban

Berlin-Brandenburg Center for Regenerative Therapies and Berlin-Brandenburg School for Regenerative Therapies, Charité Universitätsmedizin Berlin, Berlin, Germany

Sangeetha Srinivasan

Shasqi Inc., San Francisco, California, United States

Nathan A. Yee

Shasqi Inc., San Francisco, California, United States

Edgar Agustin

Department of Chemistry, University at Albany, Albany, New York, United States

Anna Koliszak

Berlin-Brandenburg Center for Regenerative Therapies, Berlin, Germany

Ethan Miller

Shasqi Inc., San Francisco, California, United States

Irfan Khan

Department of Chemistry, University at Albany, Albany, New York, United States

Ilenis Quinones

Department of Chemistry, University at Albany, Albany, New York, United States

Hasina Noory

Department of Chemistry, University at Albany, Albany, New York, United States

Christopher Motola

Department of Chemistry, University at Albany, Albany, New York, United States

Rudolf Volkmer

Institute for Medical Immunology and Leibniz-Institut für Molekulare Pharmakologie, Charité Universitätsmedizin Berlin, Berlin, Germany

Mariagrazia Di Luca

Berlin-Brandenburg Center for Regenerative Therapies, Berlin, Germany

Andrej Trampuz

Freie Universität Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of Health, Center for Musculoskeletal Surgery, Charité − Universitätsmedizin Berlin, Berlin, Germany

Maksim Royzen

Department of Chemistry, University at Albany, Albany, New York, United States

Jose M. Mejia Oneto

Shasqi Inc., San Francisco, California, United States