Investigation of serum asprosin level in patients diagnosed of polycystic ovary syndrome in adolescent age

Abstract

Polycystic ovary syndrome characterized by irregular menstruation, high serum androgen levels and infertility in the reproductive period. New markers are being studied to facilitate diagnosis. Asprosin is a peptide that is synthesized during fasting and stimulates glucose production from the liver. High levels of asprosin have been found to be associated with obesity, insulin resistance and diabetes. The aim is to answer the question 'Can serum asprosin level be used as a marker in the initial diagnosis of PCOS in adolescents without any disease?'. A total of 65 people between the ages of 12-18 who applied to the Antalya Training and Research Hospital Gynecology and Obstetrics Polyclinic between June 2020 and January 2021 were included in the study. The group was divided into two as 38 patients newly diagnosed with PCOS and 27 healthy control groups without any pathology. When the asprosin level of the cases diagnosed with PCOS and the cases in the control group were compared, it was observed that the asprosin level of the cases with PCOS was significantly higher (p=0.004). This study was a study showing that serum asprosin level can be used in the diagnosis of PCOS. It should be supported by other studies. [Med-Science 2022; 11(4.000): 1725-30]

Keywords

• pcos
• adolescent
• asprosin
• insulin resistance
• hyperandrogenism