Gametocyte-specific and all-blood-stage transmission-blocking chemotypes discovered from high throughput screening on Plasmodium falciparum gametocytes

Giacomo Paonessa; Giulia Siciliano; Rita Graziani; Cristiana Lalli; Ottavia Cecchetti; Cristina Alli; Roberto La Valle; Alessia Petrocchi; Alessio Sferrazza; Monica Bisbocci; Mario Falchi; Carlo Toniatti; Alberto Bresciani; Pietro Alano

doi:10.1038/s42003-022-03510-w

Communications Biology (Jun 2022)

Gametocyte-specific and all-blood-stage transmission-blocking chemotypes discovered from high throughput screening on Plasmodium falciparum gametocytes

Giacomo Paonessa,
Giulia Siciliano,
Rita Graziani,
Cristiana Lalli,
Ottavia Cecchetti,
Cristina Alli,
Roberto La Valle,
Alessia Petrocchi,
Alessio Sferrazza,
Monica Bisbocci,
Mario Falchi,
Carlo Toniatti,
Alberto Bresciani,
Pietro Alano

Affiliations

Giacomo Paonessa: Department of Translational and Discovery Research, IRBM S.p.A., Pomezia
Giulia Siciliano: Dipartimento di Malattie Infettive, Istituto Superiore di Sanità
Rita Graziani: Department of Translational and Discovery Research, IRBM S.p.A., Pomezia
Cristiana Lalli: Department of Translational and Discovery Research, IRBM S.p.A., Pomezia
Ottavia Cecchetti: Department of Translational and Discovery Research, IRBM S.p.A., Pomezia
Cristina Alli: Department of Translational and Discovery Research, IRBM S.p.A., Pomezia
Roberto La Valle: Dipartimento di Malattie Infettive, Istituto Superiore di Sanità
Alessia Petrocchi: Department of Drug Discovery, IRBM S.p.A., Pomezia
Alessio Sferrazza: Department of Drug Discovery, IRBM S.p.A., Pomezia
Monica Bisbocci: Department of Translational and Discovery Research, IRBM S.p.A., Pomezia
Mario Falchi: Centro Nazionale AIDS, Istituto Superiore di Sanità
Carlo Toniatti: Department of Translational and Discovery Research, IRBM S.p.A., Pomezia
Alberto Bresciani: Department of Translational and Discovery Research, IRBM S.p.A., Pomezia
Pietro Alano: Dipartimento di Malattie Infettive, Istituto Superiore di Sanità

DOI: https://doi.org/10.1038/s42003-022-03510-w
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 10

Abstract

Read online

High-throughput screening of 120,000 compounds followed by counter-screening and validation assays reveals candidate antimalarial drugs that kill Plasmodium falciparum sexual and asexual blood stages blocking parasite transmission through mosquito.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal