Nature Communications (Feb 2019)
The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species
- Didac Carmona-Gutierrez,
- Andreas Zimmermann,
- Katharina Kainz,
- Federico Pietrocola,
- Guo Chen,
- Silvia Maglioni,
- Alfonso Schiavi,
- Jihoon Nah,
- Sara Mertel,
- Christine B. Beuschel,
- Francesca Castoldi,
- Valentina Sica,
- Gert Trausinger,
- Reingard Raml,
- Cornelia Sommer,
- Sabrina Schroeder,
- Sebastian J. Hofer,
- Maria A. Bauer,
- Tobias Pendl,
- Jelena Tadic,
- Christopher Dammbrueck,
- Zehan Hu,
- Christoph Ruckenstuhl,
- Tobias Eisenberg,
- Sylvere Durand,
- Noélie Bossut,
- Fanny Aprahamian,
- Mahmoud Abdellatif,
- Simon Sedej,
- David P. Enot,
- Heimo Wolinski,
- Jörn Dengjel,
- Oliver Kepp,
- Christoph Magnes,
- Frank Sinner,
- Thomas R. Pieber,
- Junichi Sadoshima,
- Natascia Ventura,
- Stephan J. Sigrist,
- Guido Kroemer,
- Frank Madeo
Affiliations
- Didac Carmona-Gutierrez
- Institute of Molecular Biosciences, NAWI Graz, University of Graz
- Andreas Zimmermann
- Institute of Molecular Biosciences, NAWI Graz, University of Graz
- Katharina Kainz
- Institute of Molecular Biosciences, NAWI Graz, University of Graz
- Federico Pietrocola
- Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, INSERM U 1138
- Guo Chen
- Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, INSERM U 1138
- Silvia Maglioni
- IUF - Leibniz Research Institute for Environmental Medicine
- Alfonso Schiavi
- IUF - Leibniz Research Institute for Environmental Medicine
- Jihoon Nah
- Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School
- Sara Mertel
- Institute for Biology/Genetics, Freie Universität Berlin
- Christine B. Beuschel
- Institute for Biology/Genetics, Freie Universität Berlin
- Francesca Castoldi
- Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, INSERM U 1138
- Valentina Sica
- Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, INSERM U 1138
- Gert Trausinger
- Joanneum Research Forschungsgesellschaft m.b.H., HEALTH, Institute for Biomedicine and Health Sciences
- Reingard Raml
- Joanneum Research Forschungsgesellschaft m.b.H., HEALTH, Institute for Biomedicine and Health Sciences
- Cornelia Sommer
- Institute of Molecular Biosciences, NAWI Graz, University of Graz
- Sabrina Schroeder
- Institute of Molecular Biosciences, NAWI Graz, University of Graz
- Sebastian J. Hofer
- Institute of Molecular Biosciences, NAWI Graz, University of Graz
- Maria A. Bauer
- Institute of Molecular Biosciences, NAWI Graz, University of Graz
- Tobias Pendl
- Institute of Molecular Biosciences, NAWI Graz, University of Graz
- Jelena Tadic
- Institute of Molecular Biosciences, NAWI Graz, University of Graz
- Christopher Dammbrueck
- Institute of Molecular Biosciences, NAWI Graz, University of Graz
- Zehan Hu
- Department of Cardiology, Medical University of Graz
- Christoph Ruckenstuhl
- Institute of Molecular Biosciences, NAWI Graz, University of Graz
- Tobias Eisenberg
- Institute of Molecular Biosciences, NAWI Graz, University of Graz
- Sylvere Durand
- Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, INSERM U 1138
- Noélie Bossut
- Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, INSERM U 1138
- Fanny Aprahamian
- Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, INSERM U 1138
- Mahmoud Abdellatif
- Department of Cardiology, Medical University of Graz
- Simon Sedej
- Department of Cardiology, Medical University of Graz
- David P. Enot
- Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, INSERM U 1138
- Heimo Wolinski
- Institute of Molecular Biosciences, NAWI Graz, University of Graz
- Jörn Dengjel
- Department of Biology, Université de Fribourg
- Oliver Kepp
- Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, INSERM U 1138
- Christoph Magnes
- Joanneum Research Forschungsgesellschaft m.b.H., HEALTH, Institute for Biomedicine and Health Sciences
- Frank Sinner
- Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz
- Thomas R. Pieber
- Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz
- Junichi Sadoshima
- Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School
- Natascia Ventura
- IUF - Leibniz Research Institute for Environmental Medicine
- Stephan J. Sigrist
- Institute for Biology/Genetics, Freie Universität Berlin
- Guido Kroemer
- Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, INSERM U 1138
- Frank Madeo
- Institute of Molecular Biosciences, NAWI Graz, University of Graz
- DOI
- https://doi.org/10.1038/s41467-019-08555-w
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 17
Abstract
Although ageing is the most important risk factor for chronic ailments, effective interventions remain rare. Here, the authors identify the flavonoid 4,4’-dimethoxychalcone and demonstrate that it extends lifespan and promotes health in multiple organisms by inducing autophagy.
