Nature Communications (Jun 2022)
Glutamine deficiency in solid tumor cells confers resistance to ribosomal RNA synthesis inhibitors
- Melvin Pan,
- Christiane Zorbas,
- Maki Sugaya,
- Kensuke Ishiguro,
- Miki Kato,
- Miyuki Nishida,
- Hai-Feng Zhang,
- Marco M. Candeias,
- Akimitsu Okamoto,
- Takamasa Ishikawa,
- Tomoyoshi Soga,
- Hiroyuki Aburatani,
- Juro Sakai,
- Yoshihiro Matsumura,
- Tsutomu Suzuki,
- Christopher G. Proud,
- Denis L. J. Lafontaine,
- Tsuyoshi Osawa
Affiliations
- Melvin Pan
- Division of Integrative Nutriomics and Oncology, RCAST, The University of Tokyo
- Christiane Zorbas
- RNA Molecular Biology, Fonds de la Recherche Scientifique (F.R.S.-FNRS), Université Libre de Bruxelles (ULB), Biopark campus
- Maki Sugaya
- Division of Integrative Nutriomics and Oncology, RCAST, The University of Tokyo
- Kensuke Ishiguro
- Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo
- Miki Kato
- Division of Integrative Nutriomics and Oncology, RCAST, The University of Tokyo
- Miyuki Nishida
- Division of Integrative Nutriomics and Oncology, RCAST, The University of Tokyo
- Hai-Feng Zhang
- Department of Molecular Oncology, BC Cancer
- Marco M. Candeias
- Molecular and RNA Cancer Unit, Graduate School of Medicine, Kyoto University
- Akimitsu Okamoto
- Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo
- Takamasa Ishikawa
- Institute for Advanced Biosciences, Keio University
- Tomoyoshi Soga
- Institute for Advanced Biosciences, Keio University
- Hiroyuki Aburatani
- Genome Science Division, RCAST, The University of Tokyo
- Juro Sakai
- Division of Metabolic Medicine, RCAST, The University of Tokyo
- Yoshihiro Matsumura
- Division of Metabolic Medicine, RCAST, The University of Tokyo
- Tsutomu Suzuki
- Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo
- Christopher G. Proud
- Lifelong Health, South Australian Health & Medical Research Institute
- Denis L. J. Lafontaine
- RNA Molecular Biology, Fonds de la Recherche Scientifique (F.R.S.-FNRS), Université Libre de Bruxelles (ULB), Biopark campus
- Tsuyoshi Osawa
- Division of Integrative Nutriomics and Oncology, RCAST, The University of Tokyo
- DOI
- https://doi.org/10.1038/s41467-022-31418-w
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Small molecules that target RNA Polymerase I inhibit ribosome biogenesis to activate p53 through the nucleolar surveillance response pathway. Here, the authors show that p53 induction by ribosome stress is dependent on extracellular glutamine availability.
