Nature Communications (Jun 2021)
A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids
- Mina-A Jhun,
- Michael Mendelson,
- Rory Wilson,
- Rahul Gondalia,
- Roby Joehanes,
- Elias Salfati,
- Xiaoping Zhao,
- Kim Valeska Emilie Braun,
- Anh Nguyet Do,
- Åsa K. Hedman,
- Tao Zhang,
- Elena Carnero-Montoro,
- Jincheng Shen,
- Traci M. Bartz,
- Jennifer A. Brody,
- May E. Montasser,
- Jeff R. O’Connell,
- Chen Yao,
- Rui Xia,
- Eric Boerwinkle,
- Megan Grove,
- Weihua Guan,
- Pfeiffer Liliane,
- Paula Singmann,
- Martina Müller-Nurasyid,
- Thomas Meitinger,
- Christian Gieger,
- Annette Peters,
- Wei Zhao,
- Erin B. Ware,
- Jennifer A. Smith,
- Klodian Dhana,
- Joyce van Meurs,
- Andre Uitterlinden,
- Mohammad Arfan Ikram,
- Mohsen Ghanbari,
- Deugi Zhi,
- Stefan Gustafsson,
- Lars Lind,
- Shengxu Li,
- Dianjianyi Sun,
- Tim D. Spector,
- Yii-der Ida Chen,
- Coleen Damcott,
- Alan R. Shuldiner,
- Devin M. Absher,
- Steve Horvath,
- Philip S. Tsao,
- Sharon Kardia,
- Bruce M. Psaty,
- Nona Sotoodehnia,
- Jordana T. Bell,
- Erik Ingelsson,
- Wei Chen,
- Abbas Dehghan,
- Donna K. Arnett,
- Melanie Waldenberger,
- Lifang Hou,
- Eric A. Whitsel,
- Andrea Baccarelli,
- Daniel Levy,
- Myriam Fornage,
- Marguerite R. Irvin,
- Themistocles L. Assimes
Affiliations
- Mina-A Jhun
- Department of Epidemiology, University of Michigan School of Public Health
- Michael Mendelson
- Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health
- Rory Wilson
- Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Rahul Gondalia
- Department of Epidemiology, University of North Carolina
- Roby Joehanes
- Hebrew SeniorLife, Beth Israel Deaconess Medical Center, Harvard Medical School
- Elias Salfati
- Department of Medicine, Stanford University School of Medicine
- Xiaoping Zhao
- The Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston
- Kim Valeska Emilie Braun
- Department of Epidemiology, Erasmus MC University Medical Center
- Anh Nguyet Do
- Department of Epidemiology, School of Public Health, University of Alabama at Birmingham
- Åsa K. Hedman
- Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University
- Tao Zhang
- Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine
- Elena Carnero-Montoro
- Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King’s College London
- Jincheng Shen
- Department of Population Health Sciences, University of Utah
- Traci M. Bartz
- Cardiovascular Health Research Unit, Departments of Medicine and Biostatistics, University of Washington
- Jennifer A. Brody
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington
- May E. Montasser
- Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine
- Jeff R. O’Connell
- Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine
- Chen Yao
- Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health
- Rui Xia
- The Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston
- Eric Boerwinkle
- School of Public Health, University of Texas Health Science Center at Houston
- Megan Grove
- School of Public Health, University of Texas Health Science Center at Houston
- Weihua Guan
- Division of Biostatistics, School of Public Health, University of Minnesota
- Pfeiffer Liliane
- Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Paula Singmann
- Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Martina Müller-Nurasyid
- Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Thomas Meitinger
- Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University
- Christian Gieger
- Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Annette Peters
- Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Wei Zhao
- Department of Epidemiology, University of Michigan School of Public Health
- Erin B. Ware
- Department of Epidemiology, University of Michigan School of Public Health
- Jennifer A. Smith
- Department of Epidemiology, University of Michigan School of Public Health
- Klodian Dhana
- Department of Internal Medicine, Rush University Medical Center
- Joyce van Meurs
- Department of Internal Medicine, Erasmus MC University Medical Center
- Andre Uitterlinden
- Department of Internal Medicine, Erasmus MC University Medical Center
- Mohammad Arfan Ikram
- Department of Epidemiology, Erasmus MC University Medical Center
- Mohsen Ghanbari
- Department of Epidemiology, Erasmus MC University Medical Center
- Deugi Zhi
- School of Biomedical Informatics, University of Texas Health Science Center at Houston
- Stefan Gustafsson
- Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University
- Lars Lind
- Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University
- Shengxu Li
- Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine
- Dianjianyi Sun
- Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine
- Tim D. Spector
- Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King’s College London
- Yii-der Ida Chen
- Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, and Department of Pediatrics, Harbor-UCLA Medical Center
- Coleen Damcott
- Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine
- Alan R. Shuldiner
- Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine
- Devin M. Absher
- HudsonAlpha Institute for Biotechnology
- Steve Horvath
- Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles
- Philip S. Tsao
- Department of Medicine, Stanford University School of Medicine
- Sharon Kardia
- Department of Epidemiology, University of Michigan School of Public Health
- Bruce M. Psaty
- Cardiovascular Health Research Unit, Departments of Epidemiology, Medicine, and Health Services, University of Washington
- Nona Sotoodehnia
- Cardiovascular Health Research Unit, Division of Cardiology, University of Washington
- Jordana T. Bell
- Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King’s College London
- Erik Ingelsson
- Department of Medicine, Stanford University School of Medicine
- Wei Chen
- Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine
- Abbas Dehghan
- Department of Epidemiology, Erasmus MC University Medical Center
- Donna K. Arnett
- Department of Epidemiology, School of Public Health, University of Alabama at Birmingham
- Melanie Waldenberger
- Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Lifang Hou
- Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University
- Eric A. Whitsel
- Department of Epidemiology, University of North Carolina
- Andrea Baccarelli
- Department of Environmental Health Sciences, Harvard T.H. Chan School of Public Health
- Daniel Levy
- Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health
- Myriam Fornage
- The Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston
- Marguerite R. Irvin
- Department of Epidemiology, School of Public Health, University of Alabama at Birmingham
- Themistocles L. Assimes
- Department of Medicine, Stanford University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-021-23899-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
Abnormal blood lipid levels are important risk factors for cardiovascular and other various diseases. Here the authors conduct a large-scale multi-ethnic epigenome-wide association study combined with epigenetic (cis-QTL and eQTM) data, and identify CpG-lipid traits associations that are specific to or common across racial/ethnic groups.
