Nature Communications (May 2019)
Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor
- Jemima Ho,
- Xuexin Yang,
- Spyridoula-Angeliki Nikou,
- Nessim Kichik,
- Andrew Donkin,
- Nicole O. Ponde,
- Jonathan P. Richardson,
- Remi L. Gratacap,
- Linda S. Archambault,
- Christian P. Zwirner,
- Celia Murciano,
- Rhonda Henley-Smith,
- Selvam Thavaraj,
- Christopher J. Tynan,
- Sarah L. Gaffen,
- Bernhard Hube,
- Robert T. Wheeler,
- David L. Moyes,
- Julian R. Naglik
Affiliations
- Jemima Ho
- Centre for Host-Microbiome Interactions, Faculty of Dental, Oral and Craniofacial Sciences, King’s College London
- Xuexin Yang
- Centre for Host-Microbiome Interactions, Faculty of Dental, Oral and Craniofacial Sciences, King’s College London
- Spyridoula-Angeliki Nikou
- Centre for Host-Microbiome Interactions, Faculty of Dental, Oral and Craniofacial Sciences, King’s College London
- Nessim Kichik
- Centre for Host-Microbiome Interactions, Faculty of Dental, Oral and Craniofacial Sciences, King’s College London
- Andrew Donkin
- Centre for Host-Microbiome Interactions, Faculty of Dental, Oral and Craniofacial Sciences, King’s College London
- Nicole O. Ponde
- Centre for Host-Microbiome Interactions, Faculty of Dental, Oral and Craniofacial Sciences, King’s College London
- Jonathan P. Richardson
- Centre for Host-Microbiome Interactions, Faculty of Dental, Oral and Craniofacial Sciences, King’s College London
- Remi L. Gratacap
- Department of Molecular & Biomedical Science, University of Maine
- Linda S. Archambault
- Department of Molecular & Biomedical Science, University of Maine
- Christian P. Zwirner
- Department of Molecular & Biomedical Science, University of Maine
- Celia Murciano
- Centre for Host-Microbiome Interactions, Faculty of Dental, Oral and Craniofacial Sciences, King’s College London
- Rhonda Henley-Smith
- Centre for Oral, Clinical & Translational Science, Faculty of Dental, Oral and Craniofacial Sciences, King’s College London
- Selvam Thavaraj
- Centre for Oral, Clinical & Translational Science, Faculty of Dental, Oral and Craniofacial Sciences, King’s College London
- Christopher J. Tynan
- Central Laser Facility, Science and Technology Facilities Council, Research Complex at Harwell, Rutherford Appleton Laboratory
- Sarah L. Gaffen
- Division of Rheumatology and Clinical Immunology, University of Pittsburgh
- Bernhard Hube
- Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute
- Robert T. Wheeler
- Department of Molecular & Biomedical Science, University of Maine
- David L. Moyes
- Centre for Host-Microbiome Interactions, Faculty of Dental, Oral and Craniofacial Sciences, King’s College London
- Julian R. Naglik
- Centre for Host-Microbiome Interactions, Faculty of Dental, Oral and Craniofacial Sciences, King’s College London
- DOI
- https://doi.org/10.1038/s41467-019-09915-2
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 12
Abstract
Candida albicans is an opportunistic fungus primarily affecting immunocompromised patients. Here, the authors identify a novel mechanism of host immune stimulation and highlight candidalysin and EGFR signalling components as potential targets for prophylactic and therapeutic intervention of mucosal candidiasis.
