Nature Communications (Jun 2020)

Coupling of melanocyte signaling and mechanics by caveolae is required for human skin pigmentation

  • Lia Domingues,
  • Ilse Hurbain,
  • Floriane Gilles-Marsens,
  • Julia Sirés-Campos,
  • Nathalie André,
  • Melissa Dewulf,
  • Maryse Romao,
  • Christine Viaris de Lesegno,
  • Anne-Sophie Macé,
  • Cédric Blouin,
  • Christelle Guéré,
  • Katell Vié,
  • Graça Raposo,
  • Christophe Lamaze,
  • Cédric Delevoye

DOI
https://doi.org/10.1038/s41467-020-16738-z
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 14

Abstract

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Caveolae are plasma membrane invaginations playing crucial functions, like signal transduction and mechanoprotection. Here, the authors show that caveolae contribute to skin pigmentation by integrating the biochemical and mechanical response of epidermal melanocytes to extracellular cues.