Nature Communications (Dec 2017)

Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator

  • Jérôme Carayol,
  • Christian Chabert,
  • Alessandro Di Cara,
  • Claudia Armenise,
  • Gregory Lefebvre,
  • Dominique Langin,
  • Nathalie Viguerie,
  • Sylviane Metairon,
  • Wim H. M. Saris,
  • Arne Astrup,
  • Patrick Descombes,
  • Armand Valsesia,
  • Jörg Hager

DOI
https://doi.org/10.1038/s41467-017-02182-z
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 14

Abstract

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Although many genetic variants are known for obesity, their function remains largely unknown. Here, in a weight-loss intervention cohort, the authors identify protein quantitative trait loci associated with BMI at baseline and after weight loss and find FAM46A to be a regulator of leptin in adipocytes.