Research Progress on the Relationship between Mitochondrial Dysfunction and Post-stroke Depression

Abstract

Post-stroke depression (PSD) is one of the most common emotional disorders that occurs after cerebrovascular diseases, with core symptoms mainly including low mood, loss of interest, and behavioral inhibition. A large amount of evidence indicates that mitochondrial dysfunction is one of the important pathophysiological factors in the occurrence and development of depression, so we put forward the hypothesis that mitochondrial dysfunction may be one of the pathogeneses of PSD. The article reviewed the relationship between mitochondrial dysfunction and PSD from the aspects of mitochondrial energy metabolism disorder, oxidative stress, deletions, damage or mutation of mitochondrial DNA, and apoptosis, so as to clarify the specific role of mitochondrial dysfunction in the pathogenesis of PSD and provide a new theoretical basis for the development of targeted antidepressants in the future.

Keywords

• stroke|depression|post-stroke depression|mitochondrial dysfunction|oxidative stress|energy metabolism|apoptosis