Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling

Fatemeh Mirzamohammadi; Garyfallia Papaioannou; Jennifer B. Inloes; Erinn B. Rankin; Huafeng Xie; Ernestina Schipani; Stuart H. Orkin; Tatsuya Kobayashi

doi:10.1038/ncomms12047

Nature Communications (Jun 2016)

Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling

Fatemeh Mirzamohammadi,
Garyfallia Papaioannou,
Jennifer B. Inloes,
Erinn B. Rankin,
Huafeng Xie,
Ernestina Schipani,
Stuart H. Orkin,
Tatsuya Kobayashi

Affiliations

Fatemeh Mirzamohammadi: Endocrine Unit, Massachusetts General Hospital, Harvard Medical School
Garyfallia Papaioannou: Endocrine Unit, Massachusetts General Hospital, Harvard Medical School
Jennifer B. Inloes: Endocrine Unit, Massachusetts General Hospital, Harvard Medical School
Erinn B. Rankin: Division of Radiation and Cancer Biology, Department of Radiation Oncology, Center for Clinical Sciences Research, Stanford University
Huafeng Xie: Department of Pediatric Oncology, Children’s Hospital, Dana Farber Cancer Institute
Ernestina Schipani: Department of Orthopaedic Surgery, Medical School, University of Michigan
Stuart H. Orkin: Department of Pediatric Oncology, Children’s Hospital, Dana Farber Cancer Institute
Tatsuya Kobayashi: Endocrine Unit, Massachusetts General Hospital, Harvard Medical School

DOI: https://doi.org/10.1038/ncomms12047
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 10

Abstract

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Eed is a polycomb repressive complex 2 component involved in stem cell lineage determination, but little is known about its role in lineage committed cells. Here the authors show that chondrocyte-specific Eed KO mice have skeletal growth defects related to induction of Wnt and TGF-β signalling.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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