Nature Communications (Oct 2020)
Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression
- Patricia P. Yee,
- Yiju Wei,
- Soo-Yeon Kim,
- Tong Lu,
- Stephen Y. Chih,
- Cynthia Lawson,
- Miaolu Tang,
- Zhijun Liu,
- Benjamin Anderson,
- Krishnamoorthy Thamburaj,
- Megan M. Young,
- Dawit G. Aregawi,
- Michael J. Glantz,
- Brad E. Zacharia,
- Charles S. Specht,
- Hong-Gang Wang,
- Wei Li
Affiliations
- Patricia P. Yee
- Division of Hematology and Oncology, Department of Pediatrics, Penn State College of Medicine
- Yiju Wei
- Division of Hematology and Oncology, Department of Pediatrics, Penn State College of Medicine
- Soo-Yeon Kim
- Division of Hematology and Oncology, Department of Pediatrics, Penn State College of Medicine
- Tong Lu
- Division of Hematology and Oncology, Department of Pediatrics, Penn State College of Medicine
- Stephen Y. Chih
- Medical Scientist Training Program, Penn State College of Medicine
- Cynthia Lawson
- Division of Anatomic Pathology, Department of Pathology and Laboratory Medicine, Penn State College of Medicine
- Miaolu Tang
- Division of Hematology and Oncology, Department of Pediatrics, Penn State College of Medicine
- Zhijun Liu
- Division of Hematology and Oncology, Department of Pediatrics, Penn State College of Medicine
- Benjamin Anderson
- Division of Hematology and Oncology, Department of Pediatrics, Penn State College of Medicine
- Krishnamoorthy Thamburaj
- Department of Radiology, Penn State College of Medicine
- Megan M. Young
- Division of Hematology and Oncology, Department of Pediatrics, Penn State College of Medicine
- Dawit G. Aregawi
- Division of Neuro-Oncology and Skull Base Surgery, Department of Neurosurgery, Penn State College of Medicine
- Michael J. Glantz
- Division of Neuro-Oncology and Skull Base Surgery, Department of Neurosurgery, Penn State College of Medicine
- Brad E. Zacharia
- Division of Neuro-Oncology and Skull Base Surgery, Department of Neurosurgery, Penn State College of Medicine
- Charles S. Specht
- Division of Anatomic Pathology, Department of Pathology and Laboratory Medicine, Penn State College of Medicine
- Hong-Gang Wang
- Division of Hematology and Oncology, Department of Pediatrics, Penn State College of Medicine
- Wei Li
- Division of Hematology and Oncology, Department of Pediatrics, Penn State College of Medicine
- DOI
- https://doi.org/10.1038/s41467-020-19193-y
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 22
Abstract
Tumour necrosis is associated with tumour aggressiveness and poor outcomes in patients with glioblastomas, but the underlying mechanisms remain poorly understood. Here, the authors show that in a xenograft mouse model of glioblastoma, tumour-infiltrating neutrophils amplify necrosis by promoting myeloperoxidase-induced tumour cell ferroptosis.
