Chronic lymphocytic leukemia and JAK2 V617F positive essential thrombocythemia: Distinct clonal diseases?

Abstract

The coexistence of myeloproliferative neoplasia (MPN) and chronic lymphocytic leukemia (CLL) is a rare entity. The underlying pathogenetic mechanism of this association is unknown. Here, we present a case who had JAK2 V617F mutation positive essential thrombocythemia (ET) and CLL simultaneously. In our patient, we did not detect JAK2 V617F mutation in lymphoid lineage cells. This situation reduces the possibility of a common initiative pluripotent stem cell theory for these two distinct clonal haematological diseases. It is likely that the association between CLL and ET is coincidental.

Keywords

• chronic lymphocytic leukemia
• essential thrombocythemia
• JAK2 mutation