Nature Communications (Jun 2016)
The necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance
- Jérémie Gautheron,
- Mihael Vucur,
- Anne T. Schneider,
- Ilenia Severi,
- Christoph Roderburg,
- Sanchari Roy,
- Matthias Bartneck,
- Peter Schrammen,
- Mauricio Berriel Diaz,
- Josef Ehling,
- Felix Gremse,
- Felix Heymann,
- Christiane Koppe,
- Twan Lammers,
- Fabian Kiessling,
- Niels Van Best,
- Oliver Pabst,
- Gilles Courtois,
- Andreas Linkermann,
- Stefan Krautwald,
- Ulf P. Neumann,
- Frank Tacke,
- Christian Trautwein,
- Douglas R. Green,
- Thomas Longerich,
- Norbert Frey,
- Mark Luedde,
- Matthias Bluher,
- Stephan Herzig,
- Mathias Heikenwalder,
- Tom Luedde
Affiliations
- Jérémie Gautheron
- Department of Medicine III, University Hospital RWTH Aachen
- Mihael Vucur
- Department of Medicine III, University Hospital RWTH Aachen
- Anne T. Schneider
- Department of Medicine III, University Hospital RWTH Aachen
- Ilenia Severi
- Department of Experimental and Clinical Medicine, University of Ancona
- Christoph Roderburg
- Department of Medicine III, University Hospital RWTH Aachen
- Sanchari Roy
- Department of Medicine III, University Hospital RWTH Aachen
- Matthias Bartneck
- Department of Medicine III, University Hospital RWTH Aachen
- Peter Schrammen
- Department of Medicine III, University Hospital RWTH Aachen
- Mauricio Berriel Diaz
- Institute for Diabetes and Cancer IDC Helmholtz Center Munich, Neuherberg 85764 and Joint Heidelberg‐IDC Translational Diabetes Program, Inner Medicine I, Heidelberg University
- Josef Ehling
- Department for Experimental Molecular Imaging, University Clinic and Helmholtz Institute for Biomedical Engineering RWTH Aachen
- Felix Gremse
- Department for Experimental Molecular Imaging, University Clinic and Helmholtz Institute for Biomedical Engineering RWTH Aachen
- Felix Heymann
- Department of Medicine III, University Hospital RWTH Aachen
- Christiane Koppe
- Department of Medicine III, University Hospital RWTH Aachen
- Twan Lammers
- Department for Experimental Molecular Imaging, University Clinic and Helmholtz Institute for Biomedical Engineering RWTH Aachen
- Fabian Kiessling
- Department for Experimental Molecular Imaging, University Clinic and Helmholtz Institute for Biomedical Engineering RWTH Aachen
- Niels Van Best
- Institut of Medical Microbiology, University Hospital RWTH Aachen
- Oliver Pabst
- Institut of Medical Microbiology, University Hospital RWTH Aachen
- Gilles Courtois
- Inserm U1038, BIG, CEA
- Andreas Linkermann
- Division of Nephrology and Hypertension, Christian‐Albrechts‐University
- Stefan Krautwald
- Division of Nephrology and Hypertension, Christian‐Albrechts‐University
- Ulf P. Neumann
- Department of Visceral and Transplantation Surgery, University Hospital RWTH Aachen
- Frank Tacke
- Department of Medicine III, University Hospital RWTH Aachen
- Christian Trautwein
- Department of Medicine III, University Hospital RWTH Aachen
- Douglas R. Green
- Department of Immunology, St Jude Children’s Research Hospital
- Thomas Longerich
- Institute of Pathology, University Hospital RWTH Aachen
- Norbert Frey
- Department of Cardiology and Angiology, University Hospital Schleswig-Holstein, Campus Kiel
- Mark Luedde
- Department of Cardiology and Angiology, University Hospital Schleswig-Holstein, Campus Kiel
- Matthias Bluher
- Department of Medicine, University of Leipzig
- Stephan Herzig
- Institute for Diabetes and Cancer IDC Helmholtz Center Munich, Neuherberg 85764 and Joint Heidelberg‐IDC Translational Diabetes Program, Inner Medicine I, Heidelberg University
- Mathias Heikenwalder
- Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ)
- Tom Luedde
- Department of Medicine III, University Hospital RWTH Aachen
- DOI
- https://doi.org/10.1038/ncomms11869
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 16
Abstract
The kinase RIPK3 initiates necroptosis, which has been reported to promote inflammation in various pathological conditions. Here, the authors show that genetic ablation of Ripk3results in adipocyte apoptosis and white adipose tissue inflammation in obese mice, which promotes glucose intolerance.
