Neurotrophins in the pathogenesis of pulmonary hypertension and right ventricular dysfunction

Abstract

Pulmonary hypertension (PH) is a pathophysiological and hemodynamic condition that complicates the course of various diseases and negatively affects morbidity and mortality. The search for the new pathophysiological mechanisms for PH development and progression, the markers for predicting the PH course, and the possible targets for therapy remains relevant. This review is devoted to the role of neurotrophin (NT) system in PH pathogenesis, the possible use of NT and their receptors as a laboratory marker of its severity, and also as a potential target for influencing the pulmonary artery remodeling in PH. In addition, the participation of NTs in neoangiogenesis and restoration of nervous and muscle tissues was described.

Keywords

• neurotrophins
• pulmonary hypertension
• remodeling