A GABAergic Maf-expressing interneuron subset regulates the speed of locomotion in Drosophila

H. Babski; T. Jovanic; C. Surel; S. Yoshikawa; M. F Zwart; J. Valmier; J. B. Thomas; J. Enriquez; P. Carroll; A. Garcès

doi:10.1038/s41467-019-12693-6

Nature Communications (Oct 2019)

A GABAergic Maf-expressing interneuron subset regulates the speed of locomotion in Drosophila

H. Babski,
T. Jovanic,
C. Surel,
S. Yoshikawa,
M. F Zwart,
J. Valmier,
J. B. Thomas,
J. Enriquez,
P. Carroll,
A. Garcès

Affiliations

H. Babski: Inserm U1051, Institute for Neurosciences of Montpellier, University of Montpellier
T. Jovanic: Paris-Saclay Institute of Neuroscience, UMR 9717
C. Surel: Inserm U1051, Institute for Neurosciences of Montpellier, University of Montpellier
S. Yoshikawa: Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies
M. F Zwart: School of Psychology and Neuroscience, University of St Andrews
J. Valmier: Inserm U1051, Institute for Neurosciences of Montpellier, University of Montpellier
J. B. Thomas: Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies
J. Enriquez: Institut de Génomique Fonctionnelle de Lyon (IGFL), École Normale Supérieure de Lyon and Centre National de la Recherche Scientifique (CNRS)
P. Carroll: Inserm U1051, Institute for Neurosciences of Montpellier, University of Montpellier
A. Garcès: Institut de Génomique Fonctionnelle de Lyon (IGFL), École Normale Supérieure de Lyon and Centre National de la Recherche Scientifique (CNRS)

DOI: https://doi.org/10.1038/s41467-019-12693-6
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 17

Abstract

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Spinal interneurons (IN) coordinate motoneuron activity to modulate locomotion behavior. Here, the authors characterize a subset of IN subtypes expressing the Maf transcription factor Traffic Jam (TJ) and report the distinct effects of their activation on body posture and locomotion in Drosophila larvae.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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